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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The pattern of childhood hepatitis B infection in two Gambian villages
Journal of Infectious Diseases, Volume 161, No. 6, Year 1990
Notification
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Description
Serologic markers of hepatitis B virus (HBV) infection were measured in children from Manduar and Keneba, two adjacent villages in The Gambia, in 1980 and in 1984. The rate of HBV infection over the 4 years differed markedly: in Manduar 71% of children who were <5 years of age in 1980 became infected, whereas in Keneba only 37% became infected. Male children were more frequent carriers of either HBs or e antigen than were female children. Marked clustering of hepatitis B surface antigen (HBsAg) antigenemia within sibling relationships was shown in both villages. The chance of the youngest child in a household being a carrier of HBsAg was strongly related to the number of antigen-positive siblings. Four years later, 53% of children who were initially positive for HBsAg and 33%who were positive for hepatitis Be antigen still carried these antigens. Jaundice was not observed. © 1990, University of Chicago. All rights reserved.
Authors & Co-Authors
Whittle, Hilton C.
South Africa, Tygerberg
South African Medical Research Council
Inskip, Hazel M.
South Africa, Tygerberg
South African Medical Research Council
Bradley, A. K.
South Africa, Tygerberg
South African Medical Research Council
McLaughlan, K.
South Africa, Tygerberg
South African Medical Research Council
Shenton, F. C.
South Africa, Tygerberg
South African Medical Research Council
Lamb, William H.
South Africa, Tygerberg
South African Medical Research Council
Eccles, J.
South Africa, Tygerberg
South African Medical Research Council
Baker, B. A.
South Africa, Tygerberg
South African Medical Research Council
Hall, Andrew J.
United Kingdom, Cambridge
Mrc Mitochondrial Biology Unit
Statistics
Citations: 103
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.1093/infdis/161.6.1112
ISSN:
00221899
e-ISSN:
15376613
Research Areas
Infectious Diseases
Maternal And Child Health
Study Locations
Gambia
Participants Gender
Male
Female