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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The value of estrogen and progesterone receptor determinations in advanced breast cancer. Estrogen receptor level but not progesterone receptor level correlates with response to tamoxifen
Cancer, Volume 68, No. 4, Year 1991
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Description
Four hundred fifteen patients with metastatic breast cancer with known hormone receptor status received primary treatment with tamoxifen. Measured values for the estrogen receptor (ER, i.e., with estrogen binding) followed a continuous distribution (range, 3 to 1000 fmol/mg of protein). These values correlated positively with age. The response to treatment with tamoxifen correlated with the ER level, with response rates of approximately 80% when the ER level was greater than 30.1 fmol/mg of protein. Two hundred eighteen (218 of 415, 52%) patients had progesterone receptor (PR) values greater than 10 fmol/mg. The PR positivity correlated with the ER level. Patients with PR levels greater than 10 fmol/mg of protein (124 of 226, 55%) had a significantly higher response rate than those with values less than 10 fmol/mg of protein (45 of 189, 24%). However, in a multivariate analysis including both receptor levels, age, site, and number of metastases, only the ER level was significant in predicting the response to treatment with tamoxifen. A quantitative estimation of the ER level thus is the best predictor of response to hormonal treatment with tamoxifen for advanced breast cancer. Copyright © 1991 American Cancer Society
Authors & Co-Authors
Bezwoda, Werner Robert
South Africa, Johannesburg
Breast Clinic
Esser, Jan Daniel
South Africa, Johannesburg
Charlotte Maxeke Johannesburg Academic Hospital
Dansey, Roger Delemere
South Africa, Johannesburg
Breast Clinic
Kessel, Ivan
South Africa, Johannesburg
University of the Witwatersrand
Lange, Myron
South Africa, Johannesburg
Charlotte Maxeke Johannesburg Academic Hospital
Statistics
Citations: 91
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1002/1097-0142(19910815)68:4<867::AID-CNCR2820680432>3.0.CO;2-H
ISSN:
0008543X
e-ISSN:
10970142
Research Areas
Cancer
Study Approach
Quantitative