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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancer
Cancer Letters, Volume 333, No. 2, Year 2013
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Description
A prognostic impact of immunoglobulin kappa C (IGKC) expression has been described in cancer. We analysed the influence of B-cell and plasma cell markers, as well as IGKC expression, in non-small lung cancer (NSCLC) using immunohistochemistry on a tissue microarray. IGKC protein expression was independently associated with longer survival, with particular impact in the adenocarcinoma subgroup. Moreover, a correlation was seen with CD138+ cells, but not with CD20. CD138 expression revealed a comparable association with survival. In conclusion, IGKC expression in stroma-infiltrating plasma cells is a prognostic marker in NSCLC, supporting emerging treatment concepts that exploit the humoral immune response. © 2013 Elsevier Ireland Ltd.
Authors & Co-Authors
Lohr, Miriam
Unknown Affiliation
Edlund, Karolina
Unknown Affiliation
Botling, Johan
Unknown Affiliation
Hammad, Seddik
Unknown Affiliation
Hellwig, Birte
Unknown Affiliation
Othman, Amnah
Unknown Affiliation
Berglund, Anders
Unknown Affiliation
Lambe, Mats P.
Unknown Affiliation
Holmberg, Lars H.
Unknown Affiliation
Ekman, Simon
Unknown Affiliation
Bergqvist, Michael
Unknown Affiliation
Pontén, Fredrik C.
Unknown Affiliation
Cadenas, Cristina
Unknown Affiliation
Marchan, Rosemarie
Unknown Affiliation
Hengstler, Jan Georg
Unknown Affiliation
Rahnenführer, Jörg
Unknown Affiliation
Micke, P.
Unknown Affiliation
Statistics
Citations: 158
Authors: 17
Affiliations: 7
Identifiers
Doi:
10.1016/j.canlet.2013.01.036
ISSN:
03043835
Research Areas
Cancer