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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemical engineering
Molecular docking studies of some new imidazole derivatives for antimicrobial properties
Arabian Journal of Chemistry, Volume 6, No. 2, Year 2013
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Description
In modern drug designing, molecular docking is routinely used for understanding drug-receptor interaction. In the present study six imidazole derivatives containing substituted pyrazole moiety (2a,. b and 4a-d) were synthesized. Structures of the newly synthesized compounds were characterized by spectral studies. Compounds were screened for their antibacterial activity. Compound 4c was found to be potent antimicrobial against Pseudomonas aeruginosa at concentrations of 1 and 0.5. mg/mL compared to standard drug Streptomycin. All the compounds were subjected to molecular docking studies for the inhibition of the enzyme l-glutamine: d-fructose-6-phosphate amidotransferase [GlcN-6-P] (EC 2.6.1.16). The in silico molecular docking study results showed that, all the synthesized compounds having minimum binding energy and have good affinity toward the active pocket, thus, they may be considered as good inhibitor of GlcN-6-P synthase. © 2011.
Authors & Co-Authors
Vijesh, A. M.
India, Visakhapatnam
Gitam University
Isloor, Arun Mohan
India, Mangalore
National Institute of Technology Karnataka
Telkar, Sandeep
India, Shimoga
Kuvempu University
Arulmoli, T.
India, New Mangalore
Sequent Scientific Ltd.
Fun, Hoongkun Kaun
Saudi Arabia, Riyadh
King Saud University
Statistics
Citations: 114
Authors: 5
Affiliations: 5
Identifiers
Doi:
10.1016/j.arabjc.2011.10.007
ISSN:
18785352