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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Suppressive effect of zinc on antibody response to cholera toxin in children given the killed, B subunit-whole cell, oral cholera vaccine
Vaccine, Volume 22, No. 3-4, Year 2004
Notification
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Description
In a previous study, children aged 2-5 years old in Bangladesh were supplemented orally with a single dose of Vitamin A (200,000IU) and a placebo for zinc (zinc equivalent to 20mg of elemental zinc) everyday for 42 days (group A), zinc and a placebo for Vitamin A (group Z), zinc and Vitamin A (group AZ) or both placebos (group P). All children were orally immunised with two doses of the killed cholera vaccine containing whole cells and a recombinant B subunit of cholera toxin (CT). The number of children who responded with ≥4-fold vibriocidal antibody (a proxy indicator of protection against cholera) was significantly greater among the zinc-supplemented groups than among the non-zinc-supplemented groups, while Vitamin A supplementation did not appear to have any effect. The sera from these children were assayed for antibody to CT. Antibody to CT is known to exert a synergistic protective effect against cholera in animal studies, and offer significantly higher short-term protection against cholera and significant short-term protection against enterotoxigenic Escherichia coli diarrhoea in humans on oral immunisation with the cholera vaccine. Children who received zinc had significantly reduced levels of serum antibodies to CT than children who received placebos only. Factorial analysis showed a trend for zinc showing a reduction in the number of children responding with CT-antibody, while Vitamin A did not appear to have any effect. Thus, zinc enhanced vibriocidal antibody response, but suppressed CT-antibody response, suggesting that zinc supplementation has different modulating effects on vibriocidal antibody response and CT-antibody response. © 2003 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Qadri, Firdausi
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Ahmed, Tanvir U.
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Wahed, Mohammad Abdul
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Ahmed, Firoz
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Bhuiyan, Nurul Amin
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Rahman, Anisur S.Mh Hamidur
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Clemens, John David
South Korea, Seoul
International Vaccine Institute, Seoul
Black, Robert E.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Albert, Manuel John
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Kuwait, Kuwait City
Kuwait University
Statistics
Citations: 57
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1016/j.vaccine.2003.07.005
ISSN:
0264410X
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health