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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Rotavirus disease burden and impact and cost- effectiveness of a rotavirus vaccination program in Kenya
Journal of Infectious Diseases, Volume 200, No. SUPPL. 1, Year 2009
Notification
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Description
Background. The projected impact and cost-effectiveness of rotavirus vaccination are important for supporting rotavirus vaccine introduction in Africa, where limited health intervention funds are available. Methods. Hospital records, health utilization surveys, verbal autopsy data, and surveillance data on diarrheal disease were used to determine rotavirus-specific rates of hospitalization, clinic visits, and deaths due to diarrhea among children <5 years of age in Nyanza Province, Kenya. Rates were extrapolated nationally with use of provincespecific data on diarrheal illness. Direct medical costs were estimated using record review and World Health Organization estimates. Household costs were collected through parental interviews. The impact of vaccination on health burden and on the cost-effectiveness per disability-adjusted life-year and lives saved were calculated. Results. Annually in Kenya, rotavirus infection causes 19% of hospitalizations and 16% of clinic visits for diarrhea among children <5 years of age and causes 4471 deaths, 8781 hospitalizations, and 1,443,883 clinic visits. Nationally, rotavirus disease costs the health care system $10.8 million annually. Routine vaccination with a 2- dose rotavirus vaccination series would avert 2467 deaths (55%), 5724 hospitalizations (65%), and 852,589 clinic visits (59%) and would save 58 disability-adjusted life-years per 1000 children annually. At $3 per series, a program would cost $2.1 million in medical costs annually; the break-even price is $2.07 per series. Conclusions. A rotavirus vaccination program would reduce the substantial burden of rotavirus disease and the economic burden in Kenya. © 2009 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Tate, Jacqueline E.
United States, Atlanta
Centers for Disease Control and Prevention
Rheingans, Richard D.
United States, Atlanta
Emory University
O'Reilly, Ciara E.
United States, Atlanta
Centers for Disease Control and Prevention
Obonyo, Benson
Kenya, Nairobi
Kenya Medical Research Institute
Burton, Deron C.
United States, Atlanta
Centers for Disease Control and Prevention
Tornheim, Jeffrey A.
Kenya, Nairobi
Kenya Medical Research Institute
Jaron, Peter
Kenya, Nairobi
Kenya Medical Research Institute
Ochieng, Benjamin Jack Otieno
Kenya, Nairobi
Kenya Medical Research Institute
Kerin, Tara K.
United States, Atlanta
Centers for Disease Control and Prevention
Calhoun, Lisa M.
United States, Ann Arbor
University of Michigan, Ann Arbor
Hame, Mary
Kenya, Nairobi
Kenya Medical Research Institute
Laserson, Kayla F.
Kenya, Nairobi
Kenya Medical Research Institute
Breiman, Robert F.
Kenya, Nairobi
Kenya Medical Research Institute
Feikin, Daniel R.
Kenya, Nairobi
Kenya Medical Research Institute
Mintz, Eric Daniel
Kenya, Nairobi
Kenya Medical Research Institute
Widdowson, Marc Alain
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Citations: 69
Authors: 16
Affiliations: 4
Identifiers
Doi:
10.1086/605058
ISSN:
00221899
Research Areas
Disability
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Randomised Control Trial
Cross Sectional Study
Study Locations
Kenya