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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Immune Response in Chronic Schistosomiasis haematobium and mansoni: Reversibility of Alterations after Anti‐Parasitic Treatment with Praziquantel
Scandinavian Journal of Immunology, Volume 28, No. 2, Year 1988
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Description
Peripheral blood mononuclear cells from Sudanese children heavily infected with Schistosoma haematobium and 5. mansoni were examined for lymphocyte subpopulations, for mitogen and antigen responsiveness, and for natural killer (NK) cell activity before and 5 months after treatment with praziquantel. The humoral immune response was simultaneously investigated by determination of parasite‐specific IgG and IgE antibodies. IgE‐containing circulating immune complexes, and circulating schistosome antigen. A single dose treatment with praziquantel (40 mg/kg) resulted in a normalization of numerical imbalances in lymphocyte sub‐populations, a significant increase in the blastogenic response upon stimulation with adult worm antigen, phytohaemagglutinin (PHA), and concanavalin A (Con A), and restoration of natural killer (NK) cell‐mediated lysis of K562 targets. These findings were paralleled by a remarkable decrease in parasite‐specific IgE antibodies, IgE‐containing circulating immune complexes, and circulating schistosome antigen. The results indicate that the modulation of immune responses in chronic schistosomiasis is associated with active infection and is reversible after successful chemotherapy. Copyright © 1988, Wiley Blackwell. All rights reserved
Authors & Co-Authors
Feldmeier, Hermann
Germany, Berlin
Institute for Tropical Medicine
Germany, Freiburg Im Breisgau
Universitätsklinikum Freiburg
Austria, Innsbruck
Universität Innsbruck
Sudan, Khartoum
National Council for Research Sudan
France, Lille
Institut Pasteur de Lille
Gastl, Günther A.
Germany, Berlin
Institute for Tropical Medicine
Germany, Freiburg Im Breisgau
Universitätsklinikum Freiburg
Austria, Innsbruck
Universität Innsbruck
Sudan, Khartoum
National Council for Research Sudan
France, Lille
Institut Pasteur de Lille
Poggensee, Ulrich
Germany, Berlin
Institute for Tropical Medicine
Germany, Freiburg Im Breisgau
Universitätsklinikum Freiburg
Austria, Innsbruck
Universität Innsbruck
Sudan, Khartoum
National Council for Research Sudan
France, Lille
Institut Pasteur de Lille
Daffalla, Asim A.R.
Germany, Berlin
Institute for Tropical Medicine
Germany, Freiburg Im Breisgau
Universitätsklinikum Freiburg
Austria, Innsbruck
Universität Innsbruck
Sudan, Khartoum
National Council for Research Sudan
France, Lille
Institut Pasteur de Lille
Nogueira-Queiroz, José Ajax
Germany, Berlin
Institute for Tropical Medicine
Germany, Freiburg Im Breisgau
Universitätsklinikum Freiburg
Austria, Innsbruck
Universität Innsbruck
Sudan, Khartoum
National Council for Research Sudan
France, Lille
Institut Pasteur de Lille
Caprón, André R.
Germany, Berlin
Institute for Tropical Medicine
Germany, Freiburg Im Breisgau
Universitätsklinikum Freiburg
Austria, Innsbruck
Universität Innsbruck
Sudan, Khartoum
National Council for Research Sudan
France, Lille
Institut Pasteur de Lille
Peter, Hanshartmut
Germany, Berlin
Institute for Tropical Medicine
Germany, Freiburg Im Breisgau
Universitätsklinikum Freiburg
Austria, Innsbruck
Universität Innsbruck
Sudan, Khartoum
National Council for Research Sudan
France, Lille
Institut Pasteur de Lille
Statistics
Citations: 15
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1111/j.1365-3083.1988.tb02426.x
ISSN:
03009475
e-ISSN:
13653083
Research Areas
Cancer
Infectious Diseases
Maternal And Child Health