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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The Cameroon Mobile Phone SMS (CAMPS) Trial: A Randomized Trial of Text Messaging versus Usual Care for Adherence to Antiretroviral Therapy
PLoS ONE, Volume 7, No. 12, Article e46909, Year 2012
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Description
Background: Mobile phone technology is a novel way of delivering health care and improving health outcomes. This trial investigates the use of motivational mobile phone text messages (SMS) to improve adherence to antiretroviral therapy (ART) over six months. Methodology/Principal Findings: CAMPS was a single-site randomized two-arm parallel design trial in Yaoundé, Cameroon. We enrolled and randomized HIV-positive adults on ART, aged 21 years and above to receive a weekly standardized motivational text message versus usual care alone. The primary outcome was adherence measured using a visual analogue scale (VAS), number of doses missed (in the week preceding the interview) and pharmacy refill data. Outcomes were measured at 3 and 6 months. Service providers and outcome assessors were blinded to allocation. Analysis was by intention-to-treat. Between November and December 2010, 200 participants were randomized, with 101 in the intervention group and 99 in the control group. At 6 months, overall retention was 81.5%. We found no significant effect on adherence by VAS>95% (risk ratio [RR] 1.06, 95% confidence interval [CI] 0.89, 1.29; p = 0.542; reported missed doses (RR 1.01, 95% CI 0.87, 1.16; p>0.999) or number of pharmacy refills (mean difference [MD] 0.1, 95% CI: 0.23, 0.43; p = 0.617. One participant in the intervention arm reported a possible disclosure of status. Conclusions/Significance: Standardized motivational mobile phone text messages did not significantly improve adherence to ART in this study. Other types of messaging or longer term studies are recommended. Registration: 1. Pan-African Clinical Trials Registry; PACTR201011000261458 2. Clinicaltrials.gov; NCT01247181. © 2012 Mbuagbaw et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3516507/bin/pone.0046909.s001.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3516507/bin/pone.0046909.s002.doc
Authors & Co-Authors
Mbuagbaw, Lawrence C.E.
Cameroon, Yaounde
Central Hospital of Yaounde Fmbs
Canada, Hamilton
Mcmaster University
Thabane, Lehana
Canada, Hamilton
Mcmaster University
Canada, Hamilton
St. Joseph's Healthcare Hamilton
Ongolo-Zogo, Pierre
Cameroon, Yaounde
Central Hospital of Yaounde Fmbs
Lester, Richard T.
Canada, Vancouver
The University of British Columbia
Canada, Vancouver
Bc Centre for Disease Control
Mills, Edward J.
Canada, Ottawa
University of Ottawa
Smieja, Marek J.
Canada, Hamilton
Mcmaster University
Canada, Hamilton
St. Joseph's Healthcare Hamilton
Dolovich, Lisa R.
Canada, Hamilton
Mcmaster University
Kouanfack, Charles
Cameroon, Yaounde
Central Hospital of Yaounde Fmbs
Statistics
Citations: 227
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1371/journal.pone.0046909
e-ISSN:
19326203
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Randomised Control Trial
Study Locations
Cameroon