Switching the clientele: A lysine residing in the c terminus of the serotonin transporter specifies its preference for the coat protein complex ii component SEC24C

Background: The serotonin transporter (SERT) relies exclusively on SEC24 paralog C for its ER export. Results: A lysine to tyrosine mutation in the C terminus of SERT switches its preference from SEC24C to SEC24D. Conclusion: The position α2 from the RI/RL/KL export motif determines SEC24 paralog requirement. Significance: The role of SEC24C in ER export of neurotransmitter transporters is relevant to psychiatric disorders, e.g., bipolar disease and depression. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.