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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Somatic genomic variations in early human prenatal development
Current Genomics, Volume 11, No. 6, Year 2010
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Description
Only 25 to 30% of conceptions result in a live birth. There is mounting evidence that the cause for this low fecundity is an extremely high incidence of chromosomal rearrangements occurring in the cleavage stage embryo. In this review, we gather all recent evidence for an extraordinary degree of mosaicisms in early embryogenesis. The presence of the rearrangements seen in the cleavage stage embryos can explain the origins of the placental mosaicisms seen during chorion villi sampling as well as the chromosomal anomalies seen in early miscarriages. Whereas these rearrangements often lead to implantation failure and early miscarriages, natural selection of the fittest cells in the embryo is the likely mechanism leading to healthy fetuses. © 2010 Bentham Science Publishers Ltd.
Authors & Co-Authors
D'Hooghe, Thomas Maria
Belgium, Leuven
Ku Leuven
Voet, Thierry
Belgium, Leuven
Center for Human Genetics
Vermeesch, Joris Robert
Belgium, Leuven
Center for Human Genetics
Statistics
Citations: 15
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.2174/138920210793175967
ISSN:
13892029
Research Areas
Maternal And Child Health
Study Design
Cohort Study