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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Intravenous Glutamine Enhances COX-2 Activity Giving Cardioprotection
Journal of Surgical Research, Volume 152, No. 1, Year 2009
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Description
Background: Preconditioning, a highly evolutionary conserved endogenous protective response, provides the most powerful form of anti-infarct protection known. We investigated whether acute intravenous glutamine, through an effect on cyclooxygenase (COX)-2 and heat shock protein (HSP) 72, might induce preconditioning. Materials and methods: Male New Zealand white rabbits (n = 28) received either 0.5 g/kg glutamine in 0.9% saline or saline only in divided doses for 3 d. The large marginal branch of the left coronary was occluded for 30 min; cardiac function was assessed during 3 h of reperfusion, and infarct size was measured. 6-Keto-PGF-1alpha, nitrate, and malonaldehyde serum levels were determined. Hearts were taken from a further group of pretreated rabbits (n = 10) to assess myocardial COX-2 and HSP72 levels. Results: Glutamine pretreatment resulted in a 39% reduction in infarct size (30.7 ± 2.0% versus 50.4 ± 2.1% controls; P < 0.01). Myocardial COX-2 levels were significantly elevated with pretreatment (P < 0.05) and were mirrored by higher serum 6-keto-PGF-1alpha levels prior to ischemia (69 ± 13 versus 18 ± 21 pg/mL in controls, P = 0.027). There was no significant difference in myocardial HSP72 or serum nitrate levels following pretreatment, or malonaldehyde levels during reperfusion. Conclusions: Glutamine pretreatment confers anti-infarct protection through up-regulation of COX-2, a key mediator of delayed preconditioning protection. Previous confirmation of its clinical safety profile at these doses suggests an acceptable strategy for inducing preconditioning for perioperative protection. © 2009 Elsevier Inc. All rights reserved.
Authors & Co-Authors
McGuinness, Jonathan G.
Ireland, Dublin
Beaumont Hospital
Neilan, Tomas G.
Ireland, Dublin
Royal College of Surgeons in Ireland
Cummins, Robert C.
Ireland, Dublin
Beaumont Hospital
Sharkasi, Adel Al
Libya, Benghazi
University of Benghazi
Bouchier-Hayes, David J.
Ireland, Dublin
Beaumont Hospital
Redmond, John Mark
Ireland, Dublin
Beaumont Hospital
Statistics
Citations: 16
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1016/j.jss.2008.03.045
ISSN:
00224804
e-ISSN:
10958673
Research Areas
Noncommunicable Diseases
Participants Gender
Male