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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Cardenolides from Pergularia tomentosa display cytotoxic activity resulting from their potent inhibition of Na
+
/K
+
-ATPase
Journal of Natural Products, Volume 72, No. 6, Year 2009
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Description
Two new cardenolide glycosides (1 and 2), along with six known cardenolide glycosides (3-8), have been isolated from the roots of Pergularia tomentosa. In order to investigate their potential anticancer activity, these compounds were tested in an in vitro growth inhibitory assay (a MTT colorimetric assay), including six different human cancer cell lines, and for their ability to inhibit Na+/K+-ATPase activity, in addition to the morphologic changes induced in human cancer cell lines (using computer-assisted phase-contrast microscopy). The data revealed that these cardenolides displayed marked cytotoxic activity. The results obtained suggest that structural characteristics of the cardenolides studied, with the A/B rings of the steroidal skeleton trans fused and containing a single sugar in a unique "dioxanoid" attachment, confer on them specific cytotoxic properties that are distinct from those displayed by classic cardenolides such as digoxin. © 2009 American Chemical Society and American Society of Pharmacognosy.
Authors & Co-Authors
Piacente, Sonia
Italy, Salerno
Università Degli Studi Di Salerno
Masullo, Milena
Italy, Salerno
Università Degli Studi Di Salerno
De Nève, Nancy
Belgium, Brussels
Unibioscreen S.a.
Dewelle, Janique
Belgium, Brussels
Unibioscreen S.a.
Hamed, Arafa I.
Egypt, Aswan
Faculty of Science
Kiss, Robert
Belgium, Brussels
Université Libre de Bruxelles
Mijatovic, Tatjana
Belgium, Brussels
Unibioscreen S.a.
Belgium, Brussels
Université Libre de Bruxelles
Statistics
Citations: 50
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1021/np800810f
ISSN:
01633864
Research Areas
Cancer