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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Chronic lead exposure may be associated with erectile dysfunction
Journal of Sexual Medicine, Volume 4, No. 5, Year 2007
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Description
Introduction. Heavy metals constitute significant potential threats to human health in both occupational and environmental settings. Research examining the etiology of lead toxicity-induced hypertension reveals that the free radical production and lowering of inherent antioxidant reserves resulting from lead toxicity are directly related to vasoconstriction underlying lead-induced hypertension. A similar mechanism would affect smooth muscle relaxation in the cavernous tissue leading to erectile dysfunction (ED). Aim. Is to study the possible hazardous effect of chronic lead exposure on the erectile function, and to document the deposition of lead in the cavernous tissue. Methods. The study group consisted of 34 men with ED, consecutively scheduled for penile implant insertion at Cairo University Hospital, as well as 15 controls. We determined the blood lead level for the two groups by the use of atomic absorption spectrophotometry. Sixteen of the 34 patients, and none of the 15 controls, had elevated lead serum levels (above 25 [g/dL]). Main Outcome Measures. We estimated the levels of two reactive oxygen species (ROS) and four antioxidants in peripheral blood for the two groups. At the time of penile implant insertion, we prepared cavernous tissue paraffin sections stained with Mallory-Parker stain to study lead deposition. We also prepared ultrathin sections for electron microscopy. We estimated cavernous tissue lead level. Results. The ED group had significantly higher blood lead level when compared with the control group. A significant positive correlation was found between the blood lead level and cavernous tissue lead level of the ED group. Individuals with high blood lead had significantly higher levels of serum ROS and significantly lower levels of serum antioxidants, compared with those having low blood lead. Histological sections from patients with high blood lead showed deposition of grayish lead granules in the cavernous tissue. Conclusions. Chronic lead exposure may be associated with ED. © 2007 International Society for Sexual Medicine.
Authors & Co-Authors
Anis, Tarek H.
Egypt, Giza
Cairo University
ElKaraksy, Ahmed
Egypt, Giza
Cairo University
Mostafa, Taymour M.
Egypt, Giza
Cairo University
Gadalla, Amr M.
Egypt, Giza
Cairo University
Imam, Hager
Egypt, Cairo
Institute of Ophthalmology
Hamdy, Laila
Egypt, Cairo
Institute of Ophthalmology
Abu El-Alla, Omayma
Egypt, Giza
Cairo University
Statistics
Citations: 28
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1111/j.1743-6109.2007.00587.x
ISSN:
17436095
e-ISSN:
17436109
Research Areas
Health System And Policy
Noncommunicable Diseases
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Participants Gender
Male