Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Predictors of functional impairment in bipolar disorder: Results from 13 cohorts from seven countries by the global bipolar cohort collaborative
Bipolar Disorders, Volume 24, No. 7, Year 2022
Notification
URL copied to clipboard!
Description
Objectives: Persistent functional impairment is common in bipolar disorder (BD) and is influenced by a number of demographic, clinical, and cognitive features. The goal of this project was to estimate and compare the influence of key factors on community function in multiple cohorts of well-characterized samples of individuals with BD. Methods: Thirteen cohorts from 7 countries included n = 5882 individuals with BD across multiple sites. The statistical approach consisted of a systematic uniform application of analyses across sites. Each site performed a logistic regression analysis with empirically derived “higher versus lower function” as the dependent variable and selected clinical and demographic variables as predictors. Results: We found high rates of functional impairment, ranging from 41 to 75%. Lower community functioning was associated with depressive symptoms in 10 of 12 of the cohorts that included this variable in the analysis. Lower levels of education, a greater number of prior mood episodes, the presence of a comorbid substance use disorder, and a greater total number of psychotropic medications were also associated with low functioning. Conclusions: The bipolar clinical research community is poised to work together to characterize the multi-dimensional contributors to impairment and address the barriers that impede patients' complete recovery. We must also identify the core features which enable many to thrive and live successfully with BD. A large-scale, worldwide, prospective longitudinal study focused squarely on BD and its heterogeneous presentations will serve as a platform for discovery and promote major advances toward optimizing outcomes for every individual with this illness. © 2022 The Authors. Bipolar Disorders published by John Wiley & Sons Ltd.
Authors & Co-Authors
Andreassen, Ole Andreas
Norway, Oslo
Universitetet I Oslo
Berk, Michael
Australia, Geelong
Barwon Health
Australia, Melbourne
Orygen Youth Health
Biernacka, Joanna M.
United States, Rochester
Mayo Clinic
Blumberg, Hilary P.
United States, New Haven
Yale School of Medicine
Cleare, Anthony J.
United Kingdom, London
King's College London
Dubertret, Caroline
France, Paris
Institut de Psychiatrie et Neurosciences de Paris Ipnp
Etain, Bruno
France, Paris
Hôpital Fernand-widal
Eyler, Lisa Todd
United States, La Jolla
University of California, San Diego
United States, San Diego
Va San Diego Healthcare System
Forester, Brent P.
United States, Belmont
Mclean Hospital
United States, Boston
Harvard Medical School
Fullerton, Janice M.
Australia, Sydney
Neuroscience Research Australia
Australia, Sydney
Unsw Sydney
Frye, Mark A.
United States, Rochester
Mayo Clinic
Haffen, Emmanuel
France, Besancon
Université Bourgogne Franche-comté
Lagerberg, Trine Vik
Norway, Oslo
Universitetet I Oslo
Leboyer, Marion
France, Creteil
Institut Mondor de Recherche Biomédicale
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Martínez-Àran, Anabel
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
McElroy, Susan L.
United States, Mason
Lindner Center of Hope
United States, Cincinnati
University of Cincinnati College of Medicine
Mitchell, Philip B.
Australia, Sydney
Unsw Sydney
Olié, Émilie
France, Paris
Inserm
Peters, Amy T.
United States, Boston
Massachusetts General Hospital
Polosan, Mircea
France, Paris
Inserm
Sajatovic, Martha M.
United States, Cleveland
University Hospitals Case Medical Center
Samalin, Ludovic
France, Clermont-ferrand
Centre Hospitalier Universitaire de Clermont-ferrand
Strawbridge, Rebecca
United Kingdom, London
King's College London
Vieta, Eduard
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Yatham, Lakshmi N.
Canada, Vancouver
The University of British Columbia
Young, Allan H.
United Kingdom, London
King's College London
Nierenberg, Andrew Alan
United States, Boston
Massachusetts General Hospital
Statistics
Citations: 16
Authors: 27
Affiliations: 30
Identifiers
Doi:
10.1111/bdi.13208
ISSN:
13985647
Research Areas
Mental Health
Substance Abuse
Study Design
Cohort Study
Study Approach
Quantitative