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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Breast cancer in South East Asia: Comparison of presentation and outcome between a middle income and a high income country
World Journal of Surgery, Volume 36, No. 12, Year 2012
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Description
Background There are large differences in socioeconomic growth within the region of South East Asia, leading to sharp contrasts in health-systems development between countries. This study compares breast cancer presentation and outcome between patients from a high income country (Singapore) and a middle income country (Malaysia) in South East Asia. Methods Within the Singapore Malaysia Breast Cancer Registry we identified all consecutive patients diagnosed with breast cancer between 1993 and 2007 at the National University Hospital in Singapore (high income country, n = 2,141) and the University of Malaya Medical Center in Kuala Lumpur, Malaysia (middle income country, n = 3,320). We compared demographics, tumor characteristics, treatment patterns, and survival between patients from both countries. Results In Malaysia, patients were less often diagnosed with in situ breast cancer (adjusted odds ratio [ORadj] 0.2; 95 % confidence interval [95 % CI] 0.1-0.3), more likely to be diagnosed with late stage (III and IV) disease (ORadj for stage III 1.6; 95 % CI 1.3-2.0; ORadj for stage IV 1.2; 95 % CI 1.1-1.4) as compared to patients from Singapore. Univariate analysis showed that Malaysian patients were at a 72 % increased risk of death as compared to Singaporeans. After adjusting for other prognostic factors, the risk decreased by only 5 % (ORadj 1.67, 95 % CI 1.44-1.92). © Société Internationale de Chirurgie 2012.
Authors & Co-Authors
Saxena, Nakul
Singapore, Singapore City
National University of Singapore
Hartman, Mikael L.
Singapore, Singapore City
National University of Singapore
Singapore, Singapore City
Nus Yong Loo Lin School of Medicine
Bhoo-Pathy, Nirmala
Malaysia, Kuala Lumpur
Kuala Lumpur Hospital
Netherlands, Utrecht
University Medical Center Utrecht
Lim, Jennifer Nyuk Wo
United Kingdom, Leeds
University of Leeds
Aw, Tar Ching
United Arab Emirates, Al Ain
United Arab Emirates University
Iau, Phillip Tsau Choong
Singapore, Singapore City
Nus Yong Loo Lin School of Medicine
Mohd Taib, Nur Aishah
Malaysia, Kuala Lumpur
Universiti Malaya
Lee, Soochin
Singapore, Singapore City
National University Health System
Yip, Chenghar Har
Malaysia, Kuala Lumpur
Universiti Malaya
Verkooijen, Helena Marieke
Singapore, Singapore City
National University of Singapore
Netherlands, Utrecht
University Medical Center Utrecht
Statistics
Citations: 35
Authors: 10
Affiliations: 8
Identifiers
Doi:
10.1007/s00268-012-1746-2
ISSN:
03642313
e-ISSN:
14322323
Research Areas
Cancer
Health System And Policy
Study Design
Case-Control Study