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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
VAR2CSA expression on the surface of placenta-derived Plasmodium falciparum-infected erythrocytes
Journal of Infectious Diseases, Volume 198, No. 7, Year 2008
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Description
Malaria remains a major threat, in sub-Saharan Africa primarily, and the most deadly infections are those with Plasmodium falciparum. Pregnancy-associated malaria is a clinically important complication of infection; it results from a unique interaction between proteoglycans in the placental intervillous space and parasite antigens. Both placental and chondroitin sulphate A-selected parasites have high-level transcripts of a unique var gene named var2csa. However, VAR2CSA has not been consistently found by proteomic analysis of placental parasites. Contrary to this, we found VAR2CSA expressed on the surface of infected erythrocytes from placenta. Importantly, this was achieved with cross-reactive antibodies against VAR2CSA. © 2008 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Magistrado, Pamela A.
Denmark, Copenhagen
Københavns Universitet
Denmark, Copenhagen
Rigshospitalet
Salanti, Ali
Denmark, Copenhagen
Københavns Universitet
Denmark, Copenhagen
Rigshospitalet
Tuikue-Ndam, Nicaise
France, Marseille
Ird Institut de Recherche Pour le Developpement
Mwakalinga, Steven B.
Denmark, Copenhagen
Københavns Universitet
Denmark, Copenhagen
Rigshospitalet
Resende, Mafalda
Denmark, Copenhagen
Københavns Universitet
Denmark, Copenhagen
Rigshospitalet
Dahlbäck, Madeleine A.
Denmark, Copenhagen
Københavns Universitet
Denmark, Copenhagen
Rigshospitalet
Hviid, Lars
Denmark, Copenhagen
Københavns Universitet
Denmark, Copenhagen
Rigshospitalet
Lusingu, John Peter Andrea
Tanzania, Tanga
National Institute for Medical Research Tanga
G. Theander, Thor Grundtvig
Denmark, Copenhagen
Københavns Universitet
Denmark, Copenhagen
Rigshospitalet
Nielsen, M. A.
Denmark, Copenhagen
Københavns Universitet
Denmark, Copenhagen
Rigshospitalet
Denmark, Copenhagen
Centre for Medical Parasitology
Statistics
Citations: 63
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1086/591502
ISSN:
00221899
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health