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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Collagen XXVII organises the pericellular matrix in the growth plate
PLoS ONE, Volume 6, No. 12, Article e29422, Year 2011
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Description
In order to characterise the function of the novel fibrillar type XXVII collagen, a series of mice expressing mutant forms of the collagen were investigated. Mice harboring a glycine to cysteine substitution in the collagenous domain were phenotypically normal when heterozygote and displayed a mild disruption of growth plate architecture in the homozygous state. Mice expressing an 87 amino acid deletion in the collagenous domain of collagen XXVII were phenotypically normal as heterozygotes whereas homozygotes exhibited a severe chondrodysplasia and died perinatally from a lung defect. Animals expressing the 87 amino acid deletion targeted specifically to cartilage were viable but severely dwarfed. The pericellular matrix of proliferative chondrocytes was disrupted and the proliferative cells exhibited a decreased tendency to flatten and form vertical columns. Collagen XXVII plays an important structural role in the pericellular extracellular matrix of the growth plate and is required for the organisation of the proliferative zone. © 2011 Plumb et al.
Authors & Co-Authors
Plumb, Darren A.
United Kingdom, Manchester
Wellcome Trust Centre for Cell-matrix Research
United Kingdom, Manchester
The University of Manchester
United States, New York
Hospital for Special Surgery - new York
Ferrara, Laila
United Kingdom, Manchester
Wellcome Trust Centre for Cell-matrix Research
United Kingdom, Manchester
The University of Manchester
Libya, Tripoli
University of Tripoli
Torbica, Tanja
United Kingdom, Manchester
Wellcome Trust Centre for Cell-matrix Research
United Kingdom, Manchester
The University of Manchester
Knowles, Lynnette
United Kingdom, Manchester
The University of Manchester
Mironov, Aleksandr A.
United Kingdom, Manchester
The University of Manchester
Kadler, K. E.
United Kingdom, Manchester
Wellcome Trust Centre for Cell-matrix Research
United Kingdom, Manchester
The University of Manchester
Briggs, Michael D.
United Kingdom, Manchester
Wellcome Trust Centre for Cell-matrix Research
United Kingdom, Manchester
The University of Manchester
Boot-Handford, Raymond P.
United Kingdom, Manchester
Wellcome Trust Centre for Cell-matrix Research
United Kingdom, Manchester
The University of Manchester
Statistics
Citations: 43
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1371/journal.pone.0029422
e-ISSN:
19326203