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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Human papillomavirus genotype distribution and cervical squamous intraepithelial lesions among high-risk women with and without HIV-1 infection in Burkina Faso
British Journal of Cancer, Volume 95, No. 3, Year 2006
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Description
Human papillomavirus (HPV) infection and cervical squamous intraepithelial lesions (SILs) were studied in 379 high-risk women. Human papillomavirus DNA was detected in 238 of 360 (66.1%) of the beta-globin-positive cervical samples, and 467 HPV isolates belonging to 35 types were identified. Multiple (2-7 types) HPV infections were observed in 52.9% of HPV-infected women. The most prevalent HPV types were HPV-52 (14.7%), HPV-35 (9.4%), HPV-58 (9.4%), HPV-51 (8.6%), HPV-16 (7.8%), HPV-31 (7.5%), HPV-53 (6.7%), and HPV-18 (6.4%). Human immunodeficiency virus type 1 (HIV-1) seroprevalence was 36.0%. Human papillomavirus prevalence was significantly higher in HIV-1-infected women (87 vs 54%, prevalence ratio (PR)=1.61, 95% confidence interval (CI): 1.4-1.8). High-risk HPV types (71 vs 40%, PR=1.79, 95% CI: 1.5-2.2), in particular HPV-16+18 (22 vs 9%, PR=2.35, 95% CI: 1.4-4.0), and multiple HPV infections (56 vs 23%, PR=2.45, 95% CI: 1.8-3.3) were more prevalent in HIV-1-infected women. High-grade SIL (HSIL) was identified in 3.8% of the women. Human immunodeficiency virus type 1 infection was strongly associated with presence of HSIL (adjusted odds ratio=17.0; 95% CI 2.2-134.1, P=0.007) after controlling for high-risk HPV infection and other risk factors for HSIL. Nine of 14 (63%) HSIL cases were associated with HPV-16 or HPV-18 infection, and might have been prevented by an effective HPV-16/18 vaccine. © 2006 Cancer Research.
Authors & Co-Authors
Didelot-Rousseau, Marie Noelle
Unknown Affiliation
Nagot, Nicolas
Unknown Affiliation
Costes-Martineau, V.
Unknown Affiliation
Vallès, Xavier
Unknown Affiliation
Ouédraogo, Abdoulaye V.
Unknown Affiliation
Konaté, Issouf
Unknown Affiliation
Weiss, Helen Anne
Unknown Affiliation
van de Perre, Philippe
Unknown Affiliation
Mayaud, Philippe C.
Unknown Affiliation
Segondy, Michel
Unknown Affiliation
Statistics
Citations: 135
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1038/sj.bjc.6603252
e-ISSN:
15321827
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Case-Control Study
Study Locations
Burkina Faso
Participants Gender
Female