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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Severe hepatotoxicity associated with nevirapine use in HIV-infected subjects
Journal of Infectious Diseases, Volume 191, No. 6, Year 2005
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Description
Human immunodeficiency virus (HIV)-infected South African patients (n = 468) received blinded lamivudine or emtricitabine, stavudine, and either nevirapine or efavirenz (based on screening viral load). Baseline characteristics were analyzed in univariate and multivariate regression, to identify risk factors for hepatotoxicity (grade 3 or greater increase in serum aminotransferase levels). The occurrence of early hepatotoxicity was 17% in the nevirapine group and 0% in the efavirenz group and was balanced between the lamivudine and emtricitabine arms. Two subjects died of hepatic failure. Independent risk factors were body-mass index (BMI) <18.5, female sex, serum albumin level <35 g/L, mean corpuscular volume >85 fL, plasma HIV-1 RNA load <20,000 copies/mL, aspartate aminotransferase level <75 IU/L, and lactate dehydrogenase level <164 IU/L. The use of nevirapine in female patients with a low BMI should be discouraged. © 2005 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Sanne, Ian
South Africa, Johannesburg
University of the Witwatersrand
Mommeja-Marin, Herve
United States, Durham
Gilead Sciences, Inc.
Hinkle, John
United States, Durham
Gilead Sciences, Inc.
Bartlett, John A.
United States, Durham
Duke University Medical Center
Lederman, Michael M.
United States, Cleveland
University Hospitals Case Medical Center
Maartens, Gary Tuberculosis
South Africa, Cape Town
University of Cape Town
Wakeford, Charles
United States, Durham
Gilead Sciences, Inc.
Shaw, Audrey
United States, Durham
Gilead Sciences, Inc.
Quinn, Joseph B.
United States, Durham
Gilead Sciences, Inc.
Gish, Robert G.
United States, San Francisco
California Pacific Medical Center
Rousseau, F.
United States, Durham
Gilead Sciences, Inc.
Statistics
Citations: 276
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1086/428093
ISSN:
00221899
Research Areas
Infectious Diseases
Participants Gender
Female