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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Field-caught permethrin-resistant Anopheles gambiae overexpress CYP6P3, a P450 that metabolises pyrethroids
PLoS Genetics, Volume 4, No. 11, Article e1000286, Year 2008
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Description
Insects exposed to pesticides undergo strong natural selection and have developed various adaptive mechanisms to survive. Resistance to pyrethroid insecticides in the malaria vector Anopheles gambiae is receiving increasing attention because it threatens the sustainability of malaria vector control programs in sub-Saharan Africa. An understanding of the molecular mechanisms conferring pyrethroid resistance gives insight into the processes of evolution of adaptive traits and facilitates the development of simple monitoring tools and novel strategies to restore the efficacy of insecticides. For this purpose, it is essential to understand which mechanisms are important in wild mosquitoes. Here, our aim was to identify enzymes that may be important in metabolic resistance to pyrethroids by measuring gene expression for over 250 genes potentially involved in metabolic resistance in phenotyped individuals from a highly resistant, wild A. gambiae population from Ghana. A cytochrome P450, CYP6P3, was significantly overexpressed in the survivors, and we show that the translated enzyme metabolises both alpha-cyano and non-alpha-cyano pyrethroids. This is the first study to demonstrate the capacity of a P450 identified in wild A. gambiae to metabolise insecticides. The findings add to the understanding of the genetic basis of insecticide resistance in wild mosquito populations. © 2008 Müller et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2583951/bin/pgen.1000286.s001.tif
Authors & Co-Authors
Müller, Pie
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Warr, Emma
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
United Kingdom, Keele
Keele University
Stevenson, Bradley J.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Pignatelli, Patricia M.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Morgan, John C.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Steven, Andrew R.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Egyir-Yawson, Alexander
Ghana, Legon
Ghana Atomic Energy Commission
Mitchell, Sara N.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Ranson, Hilary A.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Hemingway, Janet
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Paine, Mark John Ingraham
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Donnelly, Martin J.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Statistics
Citations: 324
Authors: 12
Affiliations: 3
Identifiers
Doi:
10.1371/journal.pgen.1000286
e-ISSN:
15537404
Research Areas
Genetics And Genomics
Infectious Diseases
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Locations
Ghana