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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Distinct Gut microbiota in southeastern African and northern European infants
Journal of Pediatric Gastroenterology and Nutrition, Volume 54, No. 6, Year 2012
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Description
Background and Objective: The intestinal microbiota composition in infants reflects the early environment. Our objective was to compare the gut microbiota in 6-month-old infants living in rural Malawi with children of the same age living in urban Finland, both being breast-fed and having an age-appropriate diet typical for each area. Methods: Malawian 6-month-old infants (n=44) were compared with Finnish infants (n=31) of the same age. In both cohorts, infant stool samples were available for microbiota characterization by flow cytometry-fluorescent in situ hybridization and quantitative polymerase chain reaction methods. Results: Bifidobacteria were dominant at 6 months of age in all of the infants, although in greater proportions in Malawian (70.8%) than in Finnish infants (46.8%; P<0.001). Additional distinctions in bacterial group composition comprised Bacteroides-Prevotella (17.2% vs 4.7%; P<0.001) and Clostridium histolyticum (4.4% vs 2.8%; P=0.01), respectively. The species Bifidobacterium adolescentis, Clostridium perfringens, and Staphylococcus aureus were absent in Malawian but detected in Finnish infants. Conclusions: The gut microbiota of 6-month-old infants in a low-income country differs significantly from that in a high-income country. This may have an effect on both the energy harvest from the diet typifying malnutrition and diarrheal diseases in low-income countries and Western lifestyle diseases in high-income countries. Copyright © 2012 by European Society for Pediatric Gastroenterology.
Authors & Co-Authors
Grześkowiak, Łukasz
Finland, Turku
Turun Yliopisto
Collado, Maria Carmen
Spain, Valencia
Csic - Instituto de Agroquimica y Tecnologia de Los Alimentos Iata
Mangani, Charles
Malawi, Zomba
University of Malawi
Maleta, Kenneth Mphatso
Malawi, Zomba
University of Malawi
Laitinen, Kirsi
Finland, Turku
Turun Yliopisto
Ashorn, Per A.
Finland, Tampere
Tampere University
Isolauri, Erika
Finland, Tampere
University Hospital of Tampere
Salminen, Seppo Jaakko
Finland, Turku
Turun Yliopisto
Statistics
Citations: 149
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1097/MPG.0b013e318249039c
ISSN:
02772116
e-ISSN:
15364801
Research Areas
Food Security
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Approach
Quantitative
Study Locations
Malawi