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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Anti-inflammatory and cytotoxic activities of dietary phenolics isolated from Corchorus olitorius and Vitis vinifera
Journal of Functional Foods, Volume 5, No. 3, Year 2013
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Description
The anti-inflammatory effect of two main components in the aqueous ethanol extract of both Corchorus olitorius (Co) and Vitis vinifera (Vv), namely quercetin 3-O-β-D-4C1 galactoside and quercetin 3-O-β-D-4C1 glucuronide, respectively, were investigated. The major components were isolated and their structures elucidated. It was observed that the two extracts decreased carrageenan-induced rat paw oedema in inflammatory exudates with histopathological changes, decreased density of TNF-α immunoreactive cells, inhibited vascular permeability induced by acetic acid and increased nitric oxide production in the rat air pouch. Biochemical assays showed that extracts of both plants restored reduced glutathione level and increased superoxide dismutase activity and both were active against COX-I and COX-II enzymes inhibition. The isolated compounds inhibited COX-I and had doubled inhibition percentage effect on COX-II enzymes, as confirmed by in silico docking studies. These extracts also showed activity against metastatic melanoma, leukemia and osteosarcoma cell lines. © 2013.
Authors & Co-Authors
Handoussa, Heba
Egypt, New Cairo
Faculty of Pharmacy and Biotechnology
Hanafi, Rasha S.
Egypt, New Cairo
Faculty of Pharmacy and Biotechnology
Eddiasty, Islam
Egypt, New Cairo
Faculty of Pharmacy and Biotechnology
Elgendy, Mohamed
Italy, Milan
Istituto Europeo Di Oncologia
El-Khatib, Ahmed H.
Germany, Berlin
Humboldt-universität zu Berlin
Linscheid, Michael W.
Germany, Berlin
Humboldt-universität zu Berlin
Mahran, Laila G.
Egypt, New Cairo
Faculty of Pharmacy and Biotechnology
Ayoub, Nahla A.
Egypt, New Cairo
Faculty of Pharmacy and Biotechnology
Egypt, Cairo
Faculty of Pharmacy - Ain Shams University
Statistics
Citations: 59
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1016/j.jff.2013.04.003
ISSN:
17564646
Research Areas
Environmental