Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The magnitude and kinetics of the mucosal HIV-specific CD8+ T lymphocyte response and virus RNA load in breast milk
PLoS ONE, Volume 6, No. 8, Article e23735, Year 2011
Notification
URL copied to clipboard!
Description
Background: The risk of postnatal HIV transmission is associated with the magnitude of the milk virus load. While HIV-specific cellular immune responses control systemic virus load and are detectable in milk, the contribution of these responses to the control of virus load in milk is unknown. Methods: We assessed the magnitude of the immunodominant GagRY11 and subdominant EnvKY9-specific CD8+ T lymphocyte response in blood and milk of 10 A*3002+, HIV-infected Malawian women throughout the period of lactation and correlated this response to milk virus RNA load and markers of breast inflammation. Results: The magnitude and kinetics of the HIV-specific CD8+ T lymphocyte responses were discordant in blood and milk of the right and left breast, indicating independent regulation of these responses in each breast. However, there was no correlation between the magnitude of the HIV-specific CD8+ T lymphocyte response and the milk virus RNA load. Further, there was no correlation between the magnitude of this response and markers of breast inflammation. Conclusions: The magnitude of the HIV-specific CD8+ T lymphocyte response in milk does not appear to be solely determined by the milk virus RNA load and is likely only one of the factors contributing to maintenance of low virus load in milk. © 2011 Mahlokozera et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3160326/bin/pone.0023735.s001.tif
Authors & Co-Authors
Mahlokozera, Tatenda
United States, Boston
Harvard Medical School
Kang, Helen H.
United States, Boston
Harvard Medical School
Goonetilleke, Nilu P.
United Kingdom, Oxford
Mrc Weatherall Institute of Molecular Medicine
Stacey, Andrea R.
United Kingdom, Oxford
Nuffield Department of Medicine
Lovingood, Rachel V.
United States, Durham
Duke University School of Medicine
Denny, Thomas N.
United States, Durham
Duke University School of Medicine
Kalilani-Phiri, Linda V.
Malawi, Zomba
University of Malawi
Bunn, James Edward G.
Malawi, Zomba
University of Malawi
United Kingdom, Liverpool
Alder Hey Children's Nhs Foundation Trust
Meshnick, Steven Richard
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Borrow, Persephone
United Kingdom, Oxford
Nuffield Department of Medicine
Letvin, Norman L.
United States, Boston
Harvard Medical School
Permar, Sallie Robey
United States, Boston
Harvard Medical School
United States, Boston
Boston Children's Hospital
Statistics
Citations: 12
Authors: 12
Affiliations: 8
Identifiers
Doi:
10.1371/journal.pone.0023735
e-ISSN:
19326203
Research Areas
Infectious Diseases
Maternal And Child Health
Participants Gender
Female