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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Lack of effect of pantoprazole on the pharmacodynamics and pharmacokinetics of warfarin [see comments]
British Journal of Clinical Pharmacology, Volume 39, No. 6, Year 1995
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Description
Twenty‐six healthy males took part in this double‐blind, randomised, placebo‐controlled, two‐period, cross‐over study. Pantoprazole (40 mg) (test) or placebo (reference) were administered once daily, for 8 days, with a 3 week washout period. A single oral dose of 25 mg warfarin sodium was co‐administered with pantoprazole or placebo on Day 2 of each treatment period. The 90% confidence intervals for the 'test/reference' mean ratios of the excess AUC(0.168 h) of prothrombin time and AUC(0.168 h) of factor VII, and of Cmax, AUC and t1/2 of both R‐ and S‐warfarin fell within the equivalence range of 80% to 125%. These results suggest that pantoprazole does not alter the pharmacokinetics or pharmacodynamics of warfarin. Copyright © 1995, Wiley Blackwell. All rights reserved
Authors & Co-Authors
Duursema, L.
South Africa, Bloemfontein
University of the Free State
Müller, F. O.
South Africa, Bloemfontein
University of the Free State
Schall, Robert
South Africa, Bloemfontein
University of the Free State
Middle, Michelle Vivienne
South Africa, Bloemfontein
University of the Free State
Hundt, H. K.L.
South Africa, Bloemfontein
University of the Free State
Groenewoud, Gerhard
South Africa, Bloemfontein
University of the Free State
Steinijans, V. W.
South Africa, Bloemfontein
University of the Free State
Bliesath, H.
South Africa, Bloemfontein
University of the Free State
Statistics
Citations: 41
Authors: 8
Affiliations: 1
Identifiers
Doi:
10.1111/j.1365-2125.1995.tb05732.x
ISSN:
03065251
e-ISSN:
13652125
Research Areas
Disability
Health System And Policy