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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Assessment of antidiabetic activity and acute toxicity of leaf extracts from Physalis peruviana L. in guinea-pig
Asian Pacific Journal of Tropical Biomedicine, Volume 3, No. 11, Year 2013
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Description
Objective: To verify the antidiabetic activity of leaf extracts from Physalis peruviana L. popularly used in the Eastern part of the Democratic Republic of the Congo and to point out the possible toxicity. Methods: Aqueous decoctions prepared from dried leaves powder were administrated to guinea pigs at the dose range of 100 mg/kg to 3.2 g/kg of body weight. The hypoglycemic activity was evaluated by glucose tolerance test, loading animals with glucose 4 g/kg and measuring blood glucose concentrations at various times. The effect was compared to the control and glibenclamide as antidiabetic reference drug. Acute toxicity was evaluated by recording mortality rate, changes on blood biomarkers and damage caused to vital organs. Results: At a dose of 100 mg/kg, the aqueous extract induced a significant reduction of peak concentration at 30 min after glucose loading as compared with control or reference (P<0.05). At doses greater than 400 mg, some alterations on blood, kidney and liver markers were observed. Upper 800 mg/kg, mortality was observed with LD50 estimated at about 1 280 mg/kg. At the autopsy, vital organs were in haemorrhage and swelling state. Conclusion: The crude aqueous extracts from the leaves of Physalis peruviana L. present hypoglycemic activity in animal model, but at high doses the plant may cause severe intoxication. © 2013 Asian Pacific Tropical Biomedical Magazine.
Authors & Co-Authors
Kasali, Félicien Mushagalusa
Congo, Bukavu
Official University of Bukavu
Kadima, Justin Ntokamunda
Rwanda, Butare
University of Rwanda
Mpiana, Pius Tshimankinda
Democratic Republic Congo, Kinshasa
Universite de Kinshasa
Ngbolua, Koto te Nyiwa
Democratic Republic Congo, Kinshasa
Universite de Kinshasa
Tshibangu, Damien Sha Tshibey
Democratic Republic Congo, Kinshasa
Universite de Kinshasa
Statistics
Citations: 36
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/S2221-1691(13)60166-5
ISSN:
22211691
Study Locations
Congo
Guinea