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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Beam path toxicity in candidate organs-at-risk: Assessment of radiation emetogenesis for patients receiving head and neck intensity modulated radiotherapy
Radiotherapy and Oncology, Volume 111, No. 2, Year 2014
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Description
Background To investigate potential dose-response relationship between radiation-associated nausea and vomiting (RANV) reported during radiotherapy and candidate nausea/vomiting-associated regions of interest (CNV-ROIs) in head and neck (HNC) squamous cell carcinomas. Methods and material A total of 130 patients treated with IMRT with squamous cell carcinomas of head and neck were evaluated. For each patient, CNV-ROIs were segmented manually on planning CT images. Clinical on-treatment RANV data were reconstructed by a review of the records for all patients. Dosimetric data parameters were recorded from dose-volume histograms. Nausea and vomiting reports were concatenated as a single binary "Any N/V" variable, and as a "CTC-V2+" variable. Results The mean dose to CNV-ROIs was higher for patients experiencing RANV events. For patients receiving IMRT alone, a dose-response effect was observed with varying degrees of magnitude, at a statistically significant level for the area postrema, brainstem, dorsal vagal complex, medulla oblongata, solitary nucleus, oropharyngeal mucosa and whole brain CNV-ROIs. Conclusion RANV is a common therapy-related morbidity facing patients receiving HNC radiotherapy, and, for those receiving radiotherapy-alone, is associated with modifiable dose to specific CNS structures. © 2014 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Kocak-Uzel, Esengül
United States, Houston
University of Texas Health Science Center at Houston
Turkey, Istanbul
Sisli Etfal Hospital
Gunn, G. Brandon
United States, Houston
University of Texas Health Science Center at Houston
Colen, Rivka R.
United States, Houston
University of Texas Health Science Center at Houston
Kantor, Michael E.
United States, Houston
University of Texas Health Science Center at Houston
Mohamed, Abdallah Sherif Radwan
United States, Houston
University of Texas Health Science Center at Houston
Egypt, Alexandria
Faculty of Medicine
Schoultz-Henley, Sara
United States, Houston
University of Texas Health Science Center at Houston
Mavroidis, Paniyotis
United States, San Antonio
The University of Texas at San Antonio
Frank, Steven J.
United States, Houston
University of Texas Health Science Center at Houston
Garden, Adam Seth
United States, Houston
University of Texas Health Science Center at Houston
Beadle, Beth M.
United States, Houston
University of Texas Health Science Center at Houston
Morrison, William H.
United States, Houston
University of Texas Health Science Center at Houston
Phan, Jack
United States, Houston
University of Texas Health Science Center at Houston
Rosenthal, David I.
United States, Houston
University of Texas Health Science Center at Houston
Fuller, Clifton David
United States, Houston
University of Texas Health Science Center at Houston
Statistics
Citations: 56
Authors: 14
Affiliations: 4
Identifiers
Doi:
10.1016/j.radonc.2014.02.019
e-ISSN:
18790887
Research Areas
Cancer
Health System And Policy