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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Cytomegalovirus coinfection is associated with an increased risk of severe non-AIDS-defining events in a large cohort of HIV-infected patients
Journal of Infectious Diseases, Volume 211, No. 2, Year 2015
Notification
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Description
Background. Chronic cytomegalovirus (CMV) infection has been associated with immunosenescence and immunoactivation in the general population. In human immunodeficiency virus type 1 (HIV-1)-infected people, CMV coinfection, in addition to residual HIV replication and microbial translocation, has been proposed as a key factor in sustaining immune activation, even in individuals with a controlled HIV load. Methods. Patients from the ICONA Study with at least 1 CMV immunoglobulin G (IgG) test available without active CMV disease were included in the analysis. AIDS-defining event or AIDS-related death and severe non- AIDS-defining event or non-AIDS-related death were taken as clinical progression end points. Independent predictors of CMV were identified by multivariable logistic regression. Probabilities of reaching the end points were estimated by survival analyses. Results. A total of 6111 subjects were included, of whom 5119 (83.3%) were CMV IgG positive at baseline. Patients with CMV IgG positivity at baseline were more likely to develop a severe non-AIDS-defining event/ non-AIDS-related death (adjusted hazard ratio [HR], 1.53 [95% confidence interval {CI}, 1.08-2.16]. In particular, CMV seropositivity was an independent risk factor for cardiovascular and cerebrovascular diseases (adjusted HR, 2.27 [95% CI, .97-5.32]). Conclusions. In our study population, CMV/HIV coinfection was associated with the risk of severe non- AIDS-defining events/non-AIDS-related death, especially with cardiovascular and cerebrovascular events, independently of other prognostic factors. This finding supports a potential independent role of CMV coinfection in vascular/degenerative organ disorders in HIV-infected subjects. © The Author 2014.
Authors & Co-Authors
Angarano, Gioacchino
Unknown Affiliation
Antinori, Andrea
Unknown Affiliation
Castelli, Francesco
Unknown Affiliation
Cauda, Roberto
Unknown Affiliation
Di Perri, Giovanni
Unknown Affiliation
Galli, Massimo
Italy, Milan
Ospedale Luigi Sacco - Polo Universitario
Iardino, Rosaria
Unknown Affiliation
Ippolito, Giuseppe
Unknown Affiliation
Lazzarin, Adriano
Italy, Milan
Ospedale San Paolo
Perno, Carlo Federico
Unknown Affiliation
Viale, Pierluigi
Unknown Affiliation
Castagna, Antonella
Italy, Milan
Ospedale San Paolo
Ceccherini-Silberstein, Francesca
Unknown Affiliation
Cozzi-Lepri, Alessandro
United Kingdom, London
Ucl Medical School
Girardi, Enrico
Unknown Affiliation
Lo Caputo, Sergio
Italy, Florence
Azienda Sanitaria Di Firenze
Mussini, Cristina
Unknown Affiliation
Puoti, Massimo
Italy, Milan
Ospedale San Paolo
Andreoni, Massimo G.
Unknown Affiliation
Balotta, Claudia
Unknown Affiliation
Bonfanti, Paolo
Unknown Affiliation
Bonora, Stefano
Unknown Affiliation
Borderi, Marco
Unknown Affiliation
Capobianchi, Maria Rosaria
Unknown Affiliation
Cingolani, A.
Unknown Affiliation
Cinque, P.
Unknown Affiliation
De Luca, Andrea
Unknown Affiliation
Di Biagio, Antonio
Unknown Affiliation
Gianotti, Nicola
Unknown Affiliation
Gori, Andrea
Unknown Affiliation
Guaraldi, Giovanni
Unknown Affiliation
Lapadula, Giuseppe
Unknown Affiliation
Lichtner, Miriam
Italy, Rome
Sapienza Università Di Roma
Maggiolo, Franco
Italy, Ancona
Azienda Ospedaliera Universitaria Ospedali Riuniti, Ancona
Monno, Laura
Unknown Affiliation
Quiròs-Roldan, Eugenia
Unknown Affiliation
Rusconi, Stefano
Unknown Affiliation
Fanti, Iuri
Unknown Affiliation
Galli, Laura
Unknown Affiliation
Lorenzini, Patrizia
Unknown Affiliation
Costantini, Alberto
Unknown Affiliation
Verucchi, Gabriella
Unknown Affiliation
Quirino, Tiziana
Unknown Affiliation
Segala, D.
Unknown Affiliation
Mastroianni, Claudio Maria
Unknown Affiliation
Rizzardini, Giuliano
Italy, Milan
Ospedale San Paolo
Monforte, Antonella D’Arminio
Italy, Milan
Ospedale San Paolo
Ridolfo, Anna Lisa
Italy, Milan
Ospedale San Paolo
Carenzi, Laura
Italy, Milan
Ospedale San Paolo
Cicconi, Paola
Italy, Milan
Ospedale San Paolo
Chirianni, Antonio
Unknown Affiliation
Parruti, Giustino
Unknown Affiliation
Ursini, T.
Unknown Affiliation
Vullo, Vincenzo
Italy, Rome
Sapienza Università Di Roma
Nicastri, Emanuele
Unknown Affiliation
Acinapura, Rosa
Unknown Affiliation
Libertone, Raffaella
Unknown Affiliation
Cattelan, Anna María
Unknown Affiliation
Caramello, Pietro
Unknown Affiliation
Orofino, Giancarlo
Unknown Affiliation
Pellizzer, Giampietro P.
Unknown Affiliation
Manfrin, Vinicio
Unknown Affiliation
Saracino, Annalisa L.
Italy, Bari
Università Degli Studi Di Bari Aldo Moro
Statistics
Citations: 137
Authors: 63
Affiliations: 7
Identifiers
Doi:
10.1093/infdis/jiu417
ISSN:
00221899
Research Areas
Environmental
Infectious Diseases
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study