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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Serological survey and virus isolation of simian T‐cell leukemia/T‐lymphotropic virus type I (STLV‐I) in non‐human primates in their native countries
International Journal of Cancer, Volume 40, No. 2, Year 1987
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Description
Infection with a simian retrovirus (STLV‐I) closely related to human T‐lymphotropic virus type I (HTLV‐I) was investigated in non‐human primates living in their native countries in Africa and Asia. Serum antibodies cross‐reacting with HTLV‐I antigens were detected in 85 of 567 non‐human primates of 30 species. Seropositive animals were found among African green monkeys, olive baboons, Sykes' monkeys, mandrills and patas monkeys in several countries in Africa, and cynomolgus monkeys, Celebes macaques and siamangs in Indonesia. The frequency of seropositivity was much higher in adult than in young African green monkeys, cynomolgus monkeys and Celebes macaques. STLV‐Is were isolated by establishing II lines of virus‐producing lymphoid cells in the presence of interleukin‐2 from 5 species of seropositive non‐human primates, i.e. the African green monkey, Sykes' monkey, Celebes macaque, cynomolgus monkey and siamang. All these cell lines had T‐cell markers and Tac antigen, and the cell lines from the African green monkey and Sykes' monkeys were Leu2a+ while those from other species were Leu3a+. These cell lines expressed viral antigens reacting with human sera from adult T‐cell leukemia (ATL) patients and monoclonal antibodies (MAbs) against p19 and p24 of HTLV‐I core proteins, and produced virus particles having RNA‐dependent DNA polymerase activity. Cellular DNAs from these cell lines contained provirus sequences homologous to HTLV‐I, shown by Southern blot hybridization. The restriction patterns of these provirus genomes were different from those of HTLV‐I and were also dissimilar in the different species. Copyright © 1987 Wiley‐Liss, Inc., A Wiley Company
Authors & Co-Authors
Ishikawa, Kohichi
Japan, Tokyo
The University of Tokyo
Fukasawa, Masashi
Japan, Tokyo
The University of Tokyo
Tsujimoto, Hajime
Japan, Tokyo
The University of Tokyo
Else, James G.
Kenya, Nairobi
National Museums of Kenya
Isahakia, Mohammed A.
Kenya, Nairobi
National Museums of Kenya
Ubhi, Narinder K.
Kenya, Nairobi
National Museums of Kenya
Ishida, Takafumi
Japan, Kyoto
Kyoto University
Takenaka, Osamu
Japan, Kyoto
Kyoto University
Kawamoto, Yoshi
Japan, Kyoto
Kyoto University
Shotake, T.
Japan, Kyoto
Kyoto University
Ohsawa, Hideyuki
Japan, Kyoto
Kyoto University
Ivanoff, Bernard
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Cooper, Robert W.
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Frost, Eric Harold E.
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Grant, Francis C.
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Spriatna, Yatna
Indonesia, Depok
Universitas Indonesia
Sutarman,
Indonesia, Jakarta
Ragunan Zoo
Abe, Kenji
Japan, Tokyo
National Institute of Infectious Diseases
Yamamoto, Kohtaro
Japan, Tokyo
Tokyo Medical and Dental University
Hayami, Masanori
Japan, Tokyo
The University of Tokyo
Statistics
Citations: 68
Authors: 20
Affiliations: 9
Identifiers
Doi:
10.1002/ijc.2910400219
ISSN:
00207136
e-ISSN:
10970215
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Study Approach
Quantitative