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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Association of antibodies against phospholipids with heart valve disease in systemic lupus erythematosus
The Lancet, Volume 335, No. 8705, Year 1990
Notification
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Description
A prospective echocardiographic study was carried out on 132 consecutive patients with systemic lupus erythematosus (SLE) derived from three European university medical centres. The prevalence of valvular lesions in patients with SLE was 22·7% compared with 2·9% in a control group of 68 healthy volunteers. 50 SLE patients had antibodies against phospholipids. The prevalence of valve vegetations (8/50 [16%]) and of mitral regurgitation (19/50 [38%]) was significantly higher among the SLE patients with antiphospholipids than among those without (1 and 10/82 [1·2% and 12%], respectively). During follow-up of the patients with valvular lesions, haemodynamically significant clinical valve disease developed in 6 but surgery was required in only 1; 9 had cerebrovascular occlusions; and 7 died, although no death was due directly to the cardiac involvement. Thus, valvular heart disease, particularly affecting the mitral valve, is common in patients with SLE, and the presence of antibodies against phospholipids is associated with a higher prevalence of valvular abnormalities in these patients. © 1990.
Authors & Co-Authors
Khamashta, Munther A.
United Kingdom, London
University College London
Cervera, Ricard
United Kingdom, London
University College London
Asherson, Ronald A.
United Kingdom, London
University College London
Hughes, Graham R.V.
United Kingdom, London
University College London
Font, Josep V.
Spain, Barcelona
Hospital Clinic Barcelona
Ingelmo, Miguel
Spain, Barcelona
Hospital Clinic Barcelona
Parè, Carles
Spain, Barcelona
Hospital Clinic Barcelona
Oliver, José María
Spain, Madrid
Hospital Universitario la Paz
Statistics
Citations: 300
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1016/0140-6736(90)91373-I
ISSN:
01406736
Research Areas
Health System And Policy
Noncommunicable Diseases
Study Design
Randomised Control Trial
Cross Sectional Study
Cohort Study