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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Level and value of circulating endothelial progenitor cells in patients after acute ischemic stroke
Stroke, Volume 39, No. 1, Year 2008
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Description
BACKGROUND AND PURPOSE - Endothelial progenitor cells (EPCs) migrate from bone marrow to systemic circulation in response to tissue ischemia where they differentiate into mature endothelial cells for angiogenesis in situ. This study tested the hypothesis that the level of circulating EPCs is substantially increased and predictive of prognostic outcomes after acute ischemic stroke (IS). METHODS - The level of circulating EPCs (staining markers: CD31/CD34 [E1], CD62E/CD34 [E2], and KDR/CD34 [E3]) were examined using flow cytometry at 48 hours after acute IS in 138 consecutive patients. The EPC level was also evaluated once in 20 healthy volunteers and in 40 at-risk control subjects. RESULTS - Level of circulating EPCs (E1-3) was significantly higher in patients with IS than in at-risk control subjects (P<0.05). Additionally, EPC (E1-3) level was significantly lower in patients with severe neurological impairment (defined as a score ≥12 on the National Institutes of Health Stroke Scale) than in patients with less severe impairment (National Institutes of Health Stroke Scale < score 12) at 48 hours after IS (P<0.0001). Moreover, the EPC (E3) level was strongly correlated with improved National Institutes of Health Stroke Scale ≥4 on day 21 after IS (P=0.0004). Furthermore, low circulating EPC level was independently predictive of severe neurological impairment (National Institutes of Health Stroke Scale ≥12) at 48 hours (E1-3) and combined major adverse clinical outcomes (defined as recurrent IS, any cause of death, or National Institutes of Health Stroke Scale of ≥12) on day 90 (E1) after IS (P<0.001). CONCLUSIONS - Level of circulating EPCs is independently predictive of prognosis after IS. © 2008 American Heart Association, Inc.
Authors & Co-Authors
Yip, Hon Kan
Taiwan, Taoyuan
Chang Gung University College of Medicine
Chang, Li Teh
Taiwan, Pingtung
Meiho University
Chang, Wenneng
Taiwan, Taoyuan
Chang Gung University College of Medicine
Lu, Chenghsien
Taiwan, Taoyuan
Chang Gung University College of Medicine
Liou, Chia Wei
Taiwan, Taoyuan
Chang Gung University College of Medicine
Lan, Min Yu
Taiwan, Taoyuan
Chang Gung University College of Medicine
Liu, Josef S.
Taiwan, Taoyuan
Chang Gung University College of Medicine
Youssef, Ali Ahmed
Egypt, Ismailia
Suez Canal University Hospitals
Chang, Hseuh Wen
Taiwan, Kaohsiung
National Sun Yat-sen University
Statistics
Citations: 205
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1161/STROKEAHA.107.489401
ISSN:
00392499
Research Areas
Cancer
Noncommunicable Diseases