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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes
Nature Communications, Volume 12, No. 1, Article 5929, Year 2021
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Description
Arab populations are largely understudied, notably their genetic structure and history. Here we present an in-depth analysis of 6,218 whole genomes from Qatar, revealing extensive diversity as well as genetic ancestries representing the main founding Arab genealogical lineages of Qahtanite (Peninsular Arabs) and Adnanite (General Arabs and West Eurasian Arabs). We find that Peninsular Arabs are the closest relatives of ancient hunter-gatherers and Neolithic farmers from the Levant, and that founder Arab populations experienced multiple splitting events 12–20 kya, consistent with the aridification of Arabia and farming in the Levant, giving rise to settler and nomadic communities. In terms of recent genetic flow, we show that these ancestries contributed significantly to European, South Asian as well as South American populations, likely as a result of Islamic expansion over the past 1400 years. Notably, we characterize a large cohort of men with the ChrY J1a2b haplogroup (n = 1,491), identifying 29 unique sub-haplogroups. Finally, we leverage genotype novelty to build a reference panel of 12,432 haplotypes, demonstrating improved genotype imputation for both rare and common alleles in Arabs and the wider Middle East. © 2021, The Author(s).
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC8511259/bin/41467_2021_25287_MOESM1_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC8511259/bin/41467_2021_25287_MOESM2_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC8511259/bin/41467_2021_25287_MOESM3_ESM.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC8511259/bin/41467_2021_25287_MOESM4_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC8511259/bin/41467_2021_25287_MOESM5_ESM.zip
Authors & Co-Authors
Razali, Rozaimi Mohamad
Qatar, Doha
Sidra Medicine
Rodriguez-Flores, Juan L.
United States, New York
Weill Cornell Medicine
Aamer, Waleed
Qatar, Doha
Sidra Medicine
Aliyev, Elbay
Qatar, Doha
Sidra Medicine
Ismail, Said I.
Qatar, Doha
Qatar Foundation
Al-Muftah, Wadha Ahmed
Qatar, Doha
Qatar Foundation
Badji, Radja Messai
Qatar, Doha
Qatar Foundation
Mbarek, Hamdi
Qatar, Doha
Qatar Foundation
Saad, Chadi
Qatar, Doha
Qatar Foundation
Al-Thani, Asmaa Ali
Qatar, Doha
Qatar Foundation
Afifi, Nahla M.
Qatar, Doha
Qatar Foundation
Liu, Wei
Qatar, Doha
Sidra Medicine
Lorenz, Stephan
Qatar, Doha
Sidra Medicine
Syed, Najeeb Ashraf
Qatar, Doha
Sidra Medicine
Almabrazi, Hakeem G.
Qatar, Doha
Sidra Medicine
Temanni, Ramzi
Qatar, Doha
Sidra Medicine
al-Ali, Rashid J.
Qatar, Doha
Sidra Medicine
Albagha, Omar M.E.
Qatar, Doha
Hamad Bin Khalifa University
Chouchane, Lotfi
Qatar, Doha
Weill Cornell Medicine-qatar
Estivill, Xavier
Qatar, Doha
Sidra Medicine
Fakhro, Khalid Adnan
Qatar, Doha
Sidra Medicine
Qatar, Doha
Weill Cornell Medicine-qatar
Qatar, Doha
Hamad Bin Khalifa University
Mokrab, Younes
Qatar, Doha
Sidra Medicine
Qatar, Doha
Weill Cornell Medicine-qatar
Qatar, Doha
Hamad Bin Khalifa University
Jithesh, Puthen V.
Qatar, Doha
Hamad Bin Khalifa University
Suhre, Karsten
Qatar, Doha
Qatar Foundation
United States, New York
Weill Cornell Medicine
Clark, Andrew G.
United States, Ithaca
Cornell University
Statistics
Citations: 16
Authors: 25
Affiliations: 8
Identifiers
Doi:
10.1038/s41467-021-25287-y
ISSN:
20411723
Research Areas
Genetics And Genomics
Study Design
Cohort Study
Case Study
Study Approach
Qualitative
Participants Gender
Male