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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza
Nature Immunology, Volume 19, No. 6, Year 2018
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Description
Transcriptional profiles and host-response biomarkers are used increasingly to investigate the severity, subtype and pathogenesis of disease. We now describe whole-blood mRNA signatures and concentrations of local and systemic immunological mediators in 131 adults hospitalized with influenza, from whom extensive clinical and investigational data were obtained by MOSAIC investigators. Signatures reflective of interferon-related antiviral pathways were common up to day 4 of symptoms in patients who did not require mechanical ventilator support; in those who needed mechanical ventilation, an inflammatory, activated-neutrophil and cell-stress or death ('bacterial') pattern was seen, even early in disease. Identifiable bacterial co-infection was not necessary for this 'bacterial' signature but was able to enhance its development while attenuating the early 'viral' signature. Our findings emphasize the importance of timing and severity in the interpretation of host responses to acute viral infection and identify specific patterns of immune-system activation that might enable the development of novel diagnostic and therapeutic tools for severe influenza. © 2018 The Author(s).
Authors & Co-Authors
Dunning, Jake W.
United Kingdom, London
Imperial College London
United Kingdom, London
Public Health England
Blankley, Simon
United Kingdom, London
The Francis Crick Institute
Cox, Michael J.
United Kingdom, London
Imperial College London
Graham, Christine Marian
United Kingdom, London
The Francis Crick Institute
Bloom, Chloe I.
United Kingdom, London
The Francis Crick Institute
Chaussabel, Damien
Qatar, Doha
Sidra Medicine
Banchereau, Jacques F.J.
United States, Bar Harbor
The Jackson Laboratory
Brett, Stephen J.
United Kingdom, London
Imperial College London
Johnston, Sebastian Lennox
United Kingdom, London
Imperial College London
Hansel, Trevor T.
United Kingdom, London
Imperial College London
Levin, Michael E.
United Kingdom, London
Imperial College London
Thwaites, Ryan S.
United Kingdom, London
Imperial College London
Warner, John Oliver
United Kingdom, London
Imperial College London
Cookson, William Osmond Charles M.
United Kingdom, London
Imperial College London
Gazzard, Brian G.
United Kingdom, London
Chelsea and Westminster Hospital Nhs Foundation Trust
Hay, Alan J.
United Kingdom, London
The Francis Crick Institute
McCauley, John William
United Kingdom, London
The Francis Crick Institute
Ashby, Deborah R.
United Kingdom, London
Imperial College London
Barclay, Wendy S.
United Kingdom, London
Imperial College London
Nadel, Simon
United Kingdom, London
Imperial College London
United Kingdom, London
Imperial College Healthcare Nhs Trust
Herberg, Jethro Adam
United Kingdom, London
Imperial College London
Drumright, Lydia N.
United Kingdom, London
Imperial College London
Holmes, Alison Helen
United Kingdom, London
Imperial College London
Kon, Onn Minn
United Kingdom, London
Imperial College London
United Kingdom, London
Imperial College Healthcare Nhs Trust
Aston, Stephen J.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Gordon, Stephen B.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Hussell, Tracy
Unknown Affiliation
Zambon, Maria C.
United Kingdom, London
Public Health England
Baillie, J. Kenneth
United Kingdom, Edinburgh
The University of Edinburgh
Hume, David A.
United Kingdom, Edinburgh
The University of Edinburgh
Simmonds, Peter N.
United Kingdom, Edinburgh
The University of Edinburgh
Hayward, Andrew C.
United Kingdom, London
University College London
Smyth, Rosalind L.
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
McNamara, Paul Stephen
United Kingdom, Liverpool
University of Liverpool
Semple, Malcolm Gracie
United Kingdom, Liverpool
University of Liverpool
Nguyen-Van-Tam, Jonathan S.
United Kingdom, Nottingham
University of Nottingham
Ho, Ling Pei
United Kingdom, Oxford
University of Oxford
McMichael, Andrew James
United Kingdom, Oxford
University of Oxford
Kellam, P.
United Kingdom, Hinxton
Wellcome Sanger Institute
Adamson, Walt E.
United Kingdom, Glasgow
West of Scotland Specialist Virology Centre
Carman, William F.
United Kingdom, Glasgow
West of Scotland Specialist Virology Centre
Griffiths, Mark J.D.
Unknown Affiliation
Moffatt, Miriam F.
United Kingdom, London
Imperial College London
O’Garra, Anne
United Kingdom, London
The Francis Crick Institute
Openshaw, Peter J.M.
United Kingdom, London
Imperial College London
Statistics
Citations: 89
Authors: 45
Affiliations: 16
Identifiers
Doi:
10.1038/s41590-018-0111-5
ISSN:
15292908