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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Physical and genetic mapping of the CMT4A locus and exclusion of PMP-2 as the defect in CMT4A
Genomics, Volume 28, No. 2, Year 1995
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Description
We hare previously localized one form of the autosomal recessive Charcot-Marie-Tooth disease type 4 (CMT4A) to a 5-cM region of chromosome 8q13-q21. We now report the formation of a 7-Mb YAC contig spanning the region. This contig was used to map nine additional microsatellites and six STSs to this region, and subsequent haplotype analysis has narrowed the CMT4A flanking interval to less than 1 cM. In addition, using SSCP and our physical map, we have demonstrated that the myelin protein PMP-2, mapped by FISH to this region, is not the defect in CMT4A. © 1995 Academic Press, Inc.
Authors & Co-Authors
Othmane, Kamel Ben
United States, Durham
Duke University Medical Center
Loeb, D.
United States, Durham
Duke University Medical Center
Hayworth-Hodgte, R.
United States, Winston Salem
Bowman Grey School of Medicine
Hentati, F. F.
Tunisia, Tunis
Institut National de Neurologie Mongi-ben Hamida
Rao, Nagesh
United States, Winston Salem
Bowman Grey School of Medicine
Roses, Allen David
United States, Durham
Duke University Medical Center
Hamida, Mongi Ben
Tunisia, Tunis
Institut National de Neurologie Mongi-ben Hamida
Kunkle, Brian W.
United States, Durham
Duke University Medical Center
Vance, Jeffery M.
United States, Durham
Duke University Medical Center
Statistics
Citations: 28
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1006/geno.1995.1143
ISSN:
08887543
e-ISSN:
10898646
Research Areas
Genetics And Genomics