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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Procyanidin-rich fractions from Parkia biglobosa (Mimosaceae) leaves cause redox-sensitive endothelium-dependent relaxation involving NO and EDHF in porcine coronary artery
Journal of Ethnopharmacology, Volume 132, No. 1, Year 2010
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Description
Aim of the study: Parkia biglobosa leaves are traditionally used as an antihypertensive agent in Benin. The present study assessed the vasorelaxant activity of different Parkia biglobosa leaf extracts using isolated porcine coronary artery rings. Materials and methods: A hydroalcoholic leaf extract was submitted to a multi-step liquid-liquid fractionation with solvents of increasing polarity and the polyphenolic content of the different fractions was analyzed. Vascular reactivity of the different extracts was assessed using porcine coronary artery rings, in the presence or absence of specific pharmacological inhibitors. Results: The hydroalcoholic, ethyl acetate and butanolic extracts contained mainly procyanidins and monomeric flavonoids. Parkia biglobosa leaf crude extract induced a redox-sensitive endothelium-dependent relaxation mediated by both nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF). The fractionation of the butanolic extract generated 6 fractions, two of which induced stronger vasorelaxation than the original extract and they had a higher phenolic content. Conclusions: Parkia biglobosa leaf extract is able to induce endothelium-dependent NO- and EDHF-mediated relaxation in porcine coronary artery rings. The vasorelaxant activity is dependent on their phenolic content and appears to involve mainly procyanidins. © 2010 Elsevier Ireland Ltd.
Authors & Co-Authors
Tokoudagba, Jean Marie
France, Strasbourg
Université de Strasbourg
Benin, Cotonou
University of Abomey-calavi
Auger, Cyril
France, Strasbourg
Université de Strasbourg
Bréant, Lise
France, Strasbourg
Université de Strasbourg
N'Gom, Saliou
France, Strasbourg
Université de Strasbourg
Chabert, Philippe
France, Strasbourg
Université de Strasbourg
Idris-Khodja, Noureddine
France, Strasbourg
Université de Strasbourg
Gbaguidi, Fernand Ahokannou
Benin, Cotonou
University of Abomey-calavi
Gbénou, Joachim Djimon
Benin, Cotonou
University of Abomey-calavi
Moudachirou, Mansourou
Benin, Cotonou
University of Abomey-calavi
Lobstein, Annelise
France, Strasbourg
Université de Strasbourg
Schini-Kerth, Valérie Barbara
France, Strasbourg
Université de Strasbourg
Statistics
Citations: 37
Authors: 11
Affiliations: 2
Identifiers
Doi:
10.1016/j.jep.2010.08.031
ISSN:
03788741
Study Locations
Benin