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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
L-Carnitine supplementation improves the behavioral symptoms in autistic children
Research in Autism Spectrum Disorders, Volume 7, No. 1, Year 2013
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Description
l-Carnitine was proposed as a potential treatment for patients diagnosed with autism to ameliorate the behavioral symptoms associated with the disease. Thirty children diagnosed with autism were randomly assigned to receive (100 mg/kg bodyweight/day) of liquid l-carnitine (n = 16) or placebo (n = 14) for 6 months. Measurements included changes in childhood autism rating scale (CARS) form and free and total carnitine levels using tandem mass spectrometry. Results showed significant improvement in CARS scores (P-groups <0.001) and (P-overtime = 0.006), with statistically significant differences in free carnitine levels (P = 0.027) and total carnitine levels (P = 0.036). There was no correlation between baseline free and total carnitine levels with changes in CARS scores from zero to 6 months (r > 0.5, P > 0.05) and generally l-carnitine therapy was well tolerated. In conclusion, l-carnitine therapy (100 mg/kg bodyweight/day) administered for 6 months significantly improved the autism severity, but subsequent studies are recommended. © 2012 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Fahmy, Sarah Farid
Egypt, Cairo
Faculty of Pharmacy - Ain Shams University
El-Hamamsy, Manal Hamed
Egypt, Cairo
Faculty of Pharmacy - Ain Shams University
Zaki, Osama K.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Badary, Osama Ahmed
Egypt, Cairo
Faculty of Pharmacy - Ain Shams University
Statistics
Citations: 53
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1016/j.rasd.2012.07.006
ISSN:
17509467
e-ISSN:
18780237
Research Areas
Disability
Maternal And Child Health