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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
SAMPLING VARIABILITY AND ITS INFLUENCE ON THE DIAGNOSTIC YIELD OF PERCUTANEOUS NEEDLE BIOPSY OF THE LIVER
The Lancet, Volume 327, No. 8480, Year 1986
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Description
In an investigation to determine the influence of sampling variability on the diagnostic yield of liver biopsy, 3 consecutive samples were obtained from each of 75 patients by redirecting the biopsy needle through a single entry site. In 14·7% of patients all 3 specimens were normal, and in 36% there were similar abnormalities in all 3 specimens. In the other patients, sampling variability between specimens was present. In those patients with cirrhosis, hepatocellular carcinoma, metastatic carcinoma, or hepatic granulomas the histological abnormality was present in all 3 biopsy specimens in only 50%, 54·5%, 50%, and 18·8% of patients, respectively. No complications were recorded. These findings show that important pathology can be overlooked if only a single biopsy specimen is taken, and that the method of obtaining 3 consecutive specimens improves the diagnostic yield of liver biopsy without an associated increase in complications. © 1986.
Authors & Co-Authors
Maharaj, Breminand T.J.
South Africa, Durban
University of Kwazulu-natal
Leary, William P.P.
South Africa, Durban
University of Kwazulu-natal
Naran, Anupam D.
South Africa, Durban
University of Kwazulu-natal
Maharaj, Rajend J.
South Africa, Durban
University of Kwazulu-natal
Cooppan, Rajen M.
South Africa, Durban
University of Kwazulu-natal
Pirie, Duncan
South Africa, Durban
University of Kwazulu-natal
Pudifin, Dennis J.
South Africa, Durban
University of Kwazulu-natal
Statistics
Citations: 623
Authors: 7
Affiliations: 1
Identifiers
Doi:
10.1016/S0140-6736(86)90883-4
ISSN:
01406736
Research Areas
Cancer