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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
High burden of extended-spectrum β-lactamase-producing enterobacteriaceae in Gabon
Journal of Antimicrobial Chemotherapy, Volume 68, No. 9, Article dkt164, Year 2013
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Description
Objectives: Extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) are sporadically reported from infections in sub-Saharan Africa. Travellers returning from the tropics have a high risk of ESBL-E colonization, which suggests a high prevalence of ESBL-E in Africa. Our objective was to assess the burden of rectal ESBL-E colonization and associated risk factors in Gabon, Central Africa Patients and methods: We performed a cross-sectional study on 200 hospitalized children in Gabon, Central Africa, on rectal ESBL-E colonization and applied a standardized questionnaire to assess risk factors. The antimicrobial resistance and the type of β-lactamase (SHV, TEM and CTX-M) were analysed for each isolate. Isolates associated with nosocomial spread were further genotyped. Results: The overall colonization rate of ESBL-E was 45% (n1/490) and increased from 33.6% (n1/437) at admission to 94.1% (n1/416) during hospitalization. Risk factors for ESBL-E carriage were age, 5 years, hospitalization for =5 days and a hospital stay during the past year. All isolates were susceptible to meropenem, but non-susceptible to ciprofloxacin in 52.8% (n1/457). CTX-M-15was the predominant β-lactamase. Genotyping revealed a polyclonal structure of nosocomial isolates. Conclusions: ESBL colonization in hospitalized children in Gabon is high. The risk of nosocomial transmission of ESBL-E is a challenge in rural Africa and underlines the need for sentinel surveillance in the absence of a broad decentralized microbiology laboratory. © The Author 2013. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.
Authors & Co-Authors
Schaumburg, Frieder
Germany, Munster
Universitätsklinikum Münster
Gabon, Bp 242 Lambaréné
Centre de Recherches Médicales de Lambaréné Cermel
Alabi, Abraham Sunday
Gabon, Bp 242 Lambaréné
Centre de Recherches Médicales de Lambaréné Cermel
Germany, Tubingen
Eberhard Karls Universität Tübingen
Kokou, Cosme
Gabon
Hôpital Albert Schweitzer
Grobusch, Martín Peter
Gabon, Bp 242 Lambaréné
Centre de Recherches Médicales de Lambaréné Cermel
Germany, Tubingen
Eberhard Karls Universität Tübingen
Netherlands, Amsterdam
Centre of Tropical Medicine and Travel Medicine
Koc̈k, Robin
Germany, Munster
Universitätsklinikum Münster
Kaba, Harry
Gabon, Bp 242 Lambaréné
Centre de Recherches Médicales de Lambaréné Cermel
Germany, Tubingen
Eberhard Karls Universität Tübingen
Becker, Karsten
Germany, Munster
Universitätsklinikum Münster
Adégnika, Ayôla Akim
Gabon, Bp 242 Lambaréné
Centre de Recherches Médicales de Lambaréné Cermel
Germany, Tubingen
Eberhard Karls Universität Tübingen
Netherlands, Leiden
Leids Universitair Medisch Centrum
Kremsner, Peter G.
Gabon, Bp 242 Lambaréné
Centre de Recherches Médicales de Lambaréné Cermel
Germany, Tubingen
Eberhard Karls Universität Tübingen
Peters, Georg
Germany, Munster
Universitätsklinikum Münster
Mellmann, A. C.
Germany, Munster
Universitätsklinikum Münster
Statistics
Citations: 75
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1093/jac/dkt164
ISSN:
03057453
e-ISSN:
14602091
Research Areas
Cancer
Health System And Policy
Maternal And Child Health
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Gabon