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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Revisiting the evolution of Mycobacterium bovis
Journal of Bacteriology, Volume 187, No. 18, Year 2005
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Description
Though careful consideration has been placed towards genetic characterization of tubercle bacillus isolates causing disease in humans, those causing disease predominantly among wild and domesticated mammals have received less attention. In contrast to Mycobacterium tuberculosis, whose host range is largely specific to humans, M. bovis and "M bovis-like" organisms infect a broad range of animal species beyond their most prominent host in cattle. To determine whether strains of variable genomic content are associated with distinct distributions of disease, the DNA contents of M. bovis or M. bovis-like isolates from a variety of hosts were investigated via Affymetrix GeneChip. Consistent with previous genomic analysis of the M. tuberculosis complex (MTC), large sequence polymorphisms of putative diagnostic and biological consequence were able to unambiguously distinguish interrogated isolates. The distribution of deleted regions indicates organisms genomically removed from M. bovis and also points to structured genomic variability within M. bovis. Certain genomic profiles spanned a variety of hosts but were clustered by geography, while others associated primarily with host type. In contrast to the prevailing assumption that M. bovis has broad host capacity, genomic profiles suggest that distinct MTC lineages differentially infect a variety of mammals. From this, a phylogenetic stratification of genotypes offers a predictive framework upon which to base future genetic and phenotypic studies of the MTC. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Mostowy, Serge
Canada, Montreal
Centre Universitaire de Santé Mcgill
Inwald, Jacqueline K.
United Kingdom, Addlestone
Animal and Plant Health Agency
Gordon, Stephen V.
United Kingdom, Addlestone
Animal and Plant Health Agency
Martin, C. A.
Spain, Zaragoza
Universidad de Zaragoza
Warren, Robin Mark
South Africa, Stellenbosch
Stellenbosch University
Kremer, Kristin
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Cousins, Debbie V.
Australia, Perth
Department of Agriculture and Food Western Australia
Behr, Marcel A.
Canada, Montreal
Centre Universitaire de Santé Mcgill
Canada, Montreal
Mcgill University Health Centre, Montreal General Hospital
Statistics
Citations: 104
Authors: 8
Affiliations: 7
Identifiers
Doi:
10.1128/JB.187.18.6386-6395.2005
ISSN:
00219193
Research Areas
Genetics And Genomics