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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
HIV type 1 subtype C remains the predominant subtype in men having sex with men in Senegal
AIDS Research and Human Retroviruses, Volume 29, No. 9, Year 2013
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Description
HIV-1 epidemics are expanding among men who have sex with men in low- and middle-income countries. To confirm and further explore preliminary data in Senegal, we aimed to determine 3 years after a first study the HIV-1 genetic diversity in three different viral regions. From 109 samples available in 2007, 93 were sequenced in gag, 77 in env, and 60 in pol. Phylogenetic analysis showed that subtype C predominated (38-52%), followed by CRF02-AG (30-40%), subtype B (13-17%), and CRF09-cpx (2.6-5%). Subsubtype A3 and strains tightly linked to CRF43-02G were identified in env and gag, respectively, and 12% of the samples were unique recombinants. Six transmission chains involving two to seven individuals were identified. Some strains carried resistance mutations inside transmission chains. This study confirmed the existence of a dual epidemic in Senegal and emphasized the need to strengthen prevention programs to avoid strains intermixing between low-risk women and high-risk men. © Mary Ann Liebert, Inc.
Authors & Co-Authors
Diop-Ndiaye, Halimatou
Senegal, Dakar
Centre Hospitalier Universitaire Aristide le Dantec de Dakar
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Tchiakpé, Edmond
Senegal, Dakar
Centre Hospitalier Universitaire Aristide le Dantec de Dakar
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Vidal, Nicole
France, Montpellier
Ird Centre de Montpellier
Ndiaye, Ousseynou Khayri
Senegal, Dakar
Centre Hospitalier Universitaire Aristide le Dantec de Dakar
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Diop, Abdou Khoudia
Senegal, Dakar
Institut Dhygiène Sociale Dakar
Peeters, Martine F.
France, Montpellier
Ird Centre de Montpellier
Mboup, Souleymane
Senegal, Dakar
Centre Hospitalier Universitaire Aristide le Dantec de Dakar
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Touré-Kâne, Coumba
Senegal, Dakar
Centre Hospitalier Universitaire Aristide le Dantec de Dakar
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Statistics
Citations: 19
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1089/aid.2013.0140
ISSN:
08892229
e-ISSN:
19318405
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Senegal
Participants Gender
Male
Female