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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Morbidity in HIV-1-infected children treated or not treated with highly active antiretroviral therapy (HAART), abidjan, côte d'Ivoire, 2000-04
Journal of Tropical Pediatrics, Volume 55, No. 3, Year 2009
Notification
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Description
Background: In the 2008 UNAIDS epidemic update, 33 million people worldwide were estimated infected with HIV, including 2.2 million children. In Côte d'Ivoire, 480 000 adults and 60 000 children were HIV-infected. Studies in developed countries have shown an improvement of children's morbidity under HAART treatment. Objective: The objective of this study is to describe and compare morbidity in relation to evolution of the disease in HIV-1-infected children in Côte d'lvoire, according to symptoms and the presence or absence of HAART treatment. Methodology: A total of 273 HIV-1-infected children from age 18 months to 18 years were included from October 2000 until December 2003. Follow-up was continued until 30 September 2004. The study population was divided in three groups. Group 1 included symptomatic children treated under HAART. Group 2 included asymptomatic children who did not need HAART treatment. Group 3 included children who met criteria to be treated at inclusion but were not treated. Principal Findings: The three most common diseases in Group 1 before treatment were bronchitis, diarrhoea and ear nose and throat (ENT) diseases. Under treatment, the three most common diseases in Group 1 were bronchitis, ENT diseases and diarrhoea. The three most occurring diseases in Group 2 were bronchitis, ENT diseases and skin infectious diseases. The three most occurring diseases in Group 3 were bronchitis, diarrhoea and ENT diseases. Conclusions: The incidence of diseases was significantly lower among asymptomatic children than among symptomatic untreated children (p < 0.0001). The morbidity found in symptomatic children who received treatment was similar to that encountered in asymptomatic children. The main reason for death in all of the groups was tuberculosis. © The Author [2008]. Published by Oxford University Press. All rights reserved.
Authors & Co-Authors
Walenda, Carsten
France, Nimes
Hôpital Universitaire Carémeau
Kouakoussui, Alain
Cote D'ivoire, Abidjan
Programme Enfant Yopougon/pacci
Rouet, François
Cote D'ivoire, Abidjan
Cedres
Wemin, Louise
Cote D'ivoire, Abidjan
Programme Enfant Yopougon/pacci
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Anaky, Marie France
Cote D'ivoire, Abidjan
Programme Enfant Yopougon/pacci
Msellati, Philippe
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
France, Aix-en-provence
Crecss
Statistics
Citations: 10
Authors: 6
Affiliations: 6
Identifiers
Doi:
10.1093/tropej/fmn106
ISSN:
01426338
e-ISSN:
14653664
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Ivory Coast