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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Cervical Intraepithelial Neoplasia and Human Papillomavirus Infection among Senegalese Women Seropositive for HIV-1 or HIV-2 or Seronegative for HIV
International Journal of STD and AIDS, Volume 5, No. 3, Year 1994
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Description
Studies in various regions of the world have shown that women infected with HIV-1 are at increased risk for cervical human papillomavirus (HPV) infection as well as for cervical cancer precursor lesions. HIV infection and cervical cancer are both widespread in West Africa, but little is known about the relationship between HPV and HIV-2, which is the predominant type of HIV in the general population of many West African countries. To address this issue, we collected cervical samples for cytology and HPV analysis from 93 women presenting to the University of Dakar Infectious Disease Service (18 women with HIV-1 infection, 17 with HIV-2 infection, and 58 HIV seronegative controls). Compared to those without HIV infection, HIV seropositive women were 13.1 (95% CI = 2.4, 128) and 11.0 (95% CI = 3.5, 35.8) times more likely to have HPV detected using Southern transfer hybridization (STH) and the polymerase chain reaction (PCR) respectively. Detection of high and intermediate risk HPV types were significantly associated with HIV-1 and HIV-2 infection. Among HPV positive women, those with, as compared to those without HIV infection were more likely to harbour high risk HPV types (OR = 9.2, 95% CI = 0.97, 433). HIV-1 and HIV-2 seropositive women were 23.3 (95% CI = 2.9, 209) and 9.3 (95% CI = 1.1, 79) times more likely to have a cytological diagnosis of dysplasia, respectively, than were HIV seronegative women. Biopsy-proven CIN 3 was found in one woman with HIV-1 and invasive cancer was found in one woman with HIV-2. It remains to be seen whether HIV-1 and HIV-2 will confer similar risks of development of CIN 2 3 and potentially of invasive cervical cancer. © 1994, SAGE Publications. All rights reserved.
Authors & Co-Authors
Seek, Awa Coll
United States, Seattle
University of Washington
Faye, Mama Awa
United States, Seattle
University of Washington
Mbaye, Adia Diack
United States, Seattle
University of Washington
Woto-Gaye, Giselle
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Senegal, Dakar
Institut Dhygiène Sociale Dakar
Kuypers, Jane M.
United States, Seattle
University of Washington
Kiviat, Nancy B.
United States, Seattle
University of Washington
Langley, Carol L.
United States, Seattle
University of Washington School of Medicine
Holmes, King Kennard
United States, Seattle
University of Washington School of Medicine
Critchlow, Cathy W.
United States, Seattle
University of Washington
Statistics
Citations: 46
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1177/095646249400500307
ISSN:
09564624
e-ISSN:
17581052
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Multi-countries
Participants Gender
Female