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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Dopamine receptor DRD2 genotype and smoking cessation outcome following treatment with bupropion SR
Pharmacogenomics Journal, Volume 5, No. 1, Year 2005
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Description
The A1 allele of the dopamine D2 receptor gene (DRD2) is associated with a reduced number of dopamine binding sites in the brain and with the increased likelihood of substance abuse and addictive behavior. In a study of smokers enrolled in an open-label, randomized effectiveness trial, we investigated whether variants in the DRD2 receptor gene are associated with smoking cessation outcomes following treatment with a combination of bupropion SR and behavioral counseling. Adherence to treatment and point-prevalent smoking status were assessed at 3 and 12 months, respectively, following a target quit date. Compared to women who carry both A2 alleles, women with at least one A1 allele were more likely to report having stopped taking bupropion due to medication side effects (odds ratio (OR)=1.91, 95% confidence interval (CI)=1.01-3.60; P<0.04) and at 12 months were somewhat more likely to report smoking (OR=0.76, 95% CI=0.56-1.03; P<0.076). Significant associations or trends were not observed in men. In women, individual variability in responsiveness to bupropion-based treatment may be partially due to differences in genetic variants influencing dopamine receptor function. © 2005 Nature Publishing Group All rights reserved.
Authors & Co-Authors
Swan, Gerald E.
United States, Menlo Park
Sri International
Statistics
Citations: 103
Authors: 1
Affiliations: 5
Identifiers
Doi:
10.1038/sj.tpj.6500281
ISSN:
1470269X
Research Areas
Genetics And Genomics
Substance Abuse
Study Design
Case-Control Study
Participants Gender
Male
Female