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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Lipoprotein(a) concentrations in rheumatoid arthritis on biologic therapy: Results from the CARdiovascular in rheuMAtology study project
Journal of Clinical Lipidology, Volume 11, No. 3, Year 2017
Notification
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Description
Background Plasma concentrations of lipoprotein (a) (Lp(a)), a lipoprotein with atherogenic and thrombogenic properties, have a strong genetic basis, although high concentrations of Lp(a) have also been reported in the context of inflammation, as in rheumatoid arthritis (RA). Few studies evaluate the impact of biologic therapies (BT) on Lp(a) in RA, taking into account that with these new therapies a better control of inflammation is achieved. Objective The aim of the study was to evaluate the plasma concentrations of Lp(a) in Spanish RA patients on BT attending rheumatology outpatient clinics. Methods Baseline analysis of the CARdiovascular in rheuMAtology project, a 10-year prospective study, evaluating the risk of cardiovascular events in RA and other forms of inflammatory arthritis. RA patients were classified according to treatment: no biologic, anti-tumor necrosis factor, anti-interleukin-6 receptor tocilizumab (TCZ), and other biologic (rituximab or abatacept). A model of linear multivariate regression was built in which the dependent variable was Lp(a) concentration and the explanatory variable was BT. The model was adjusted for confounding factors. Results Seven hundred and seventy-five RA patients were analyzed. Plasma concentrations of total cholesterol and triglyceride were significantly higher in TCZ-treated patients. Nevertheless, no significant difference in the atherogenic index between TCZ-treated patients and patients without BT was found. After adjusting for confounding factors, patients with BT had lower concentrations of Lp(a) than those without BT; however, only TCZ-treated patients achieved statistically significant differences (β: −0.303, 95% confidence interval: −0.558 to −0.047; P = .02). Conclusions RA patients treated with TCZ show lower plasma concentrations of Lp(a) compared with patients without BT. © 2017 National Lipid Association
Authors & Co-Authors
García-Gómez, Carmen
Spain, Terrassa
Consorci Sanitari de Terrassa
Martín-Martínez, María Auxiliadora
Spain, Madrid
Sociedad Española de Reumatología
Castañeda, Santos
Spain, Madrid
Hospital Universitario de la Princesa
Sánchez-Alonso, Fernando
Spain, Madrid
Sociedad Española de Reumatología
Uriarte-Ecenarro, Miren
Spain, Donostia-san Sebastian
Osakidetza, Donostia University Hospital
González-Juanatey, Carlos
Spain, Lugo
Hospital Lucus Augusti
Romera Baurés, Montserrat
Spain, Barcelona
Hospital Universitari de Bellvitge
Santos-Rey, José
Spain, Toledo
Complejo Hospitalario de Toledo
Tornero-Molina, Jesús
Spain, Guadalajara
Hospital Universitario de Guadalajara
Cobo-Ibañez, Tatiana
Spain, San Sebastian de Los Reyes
Hospital Universitario Infanta Sofía
Chamizo-Carmona, Eugenio
Spain, Badajoz
Hospital de Mérida
Díaz-González, Federico J.
Spain, Madrid
Sociedad Española de Reumatología
Spain, San Cristobal de la Laguna
Universidad de la Laguna
Spain, Santa Cruz de Tenerife
Hospital Universitario de Canarias
Llorca-Díaz, Javier Francisco
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
González-Gay, Miguel Ángel
Spain, Santander
Universidad de Cantabria
de Rábago, Eugenia González Díaz
Unknown Affiliation
Villar, Natividad Oreiro
Unknown Affiliation
Sandoval, Antonio Atanes
Unknown Affiliation
Blanco, F. J.
Unknown Affiliation
Alegre, Cayetano
Unknown Affiliation
González-Fernández, Mariángeles J.
Unknown Affiliation
Codina, Ramón Huguet
Unknown Affiliation
Yoldi, Beatriz
Unknown Affiliation
Ramentol, Mercedes
Unknown Affiliation
Ávila, Gabriela
Unknown Affiliation
Barril, Sara Marsal
Unknown Affiliation
Steiner, Martina
Unknown Affiliation
Muñoz, Santiago
Unknown Affiliation
Gamero, Fernando
Unknown Affiliation
Torón, José García
Unknown Affiliation
Moreno-Gil, María P.
Unknown Affiliation
Más, Antoni Juan
Unknown Affiliation
Espiño, Pilar
Unknown Affiliation
Ros, Inmaculada
Unknown Affiliation
Ibáñez, Mónica
Unknown Affiliation
Murillo, Claudia
Unknown Affiliation
Sanmartí, Raimón
Unknown Affiliation
Berman, Horacio
Unknown Affiliation
Cabrera, Sonia
Unknown Affiliation
Ruíz, Virginia
Unknown Affiliation
Patón, Oscar Fontseré
Unknown Affiliation
Gutiérrez, Benjamín Fernández
Unknown Affiliation
Abásolo, Lydia
Unknown Affiliation
Nolla, Joan Miquel
Unknown Affiliation
Arias, Miriam García
Unknown Affiliation
Garcia-Vadillo, Alberto
Unknown Affiliation
de Vicuña, Rosario García
Unknown Affiliation
Nebro, Antonio Fernández
Unknown Affiliation
Belmonte-López, María Ángeles
Unknown Affiliation
Ureña-Garnica, Inmaculada
Unknown Affiliation
Irigoyen, María Victoria
Unknown Affiliation
Cagigal, Virginia Coret
Unknown Affiliation
Garrido, Daniel Pielfort
Unknown Affiliation
García-Aparicio, Ángel María
Unknown Affiliation
Gómez, Rebeca Belmonte
Unknown Affiliation
Bautista, Pastora Granados
Unknown Affiliation
Sanz, Azucena Hernández
Unknown Affiliation
Sánchez-González, Carmen Olga
Unknown Affiliation
Bachiller-Corral, Javier
Unknown Affiliation
Manero, Francisco J.
Unknown Affiliation
Zorzo, Fernando Jiménez
Unknown Affiliation
Úbeda, Eugenio Giménez
Unknown Affiliation
Gracía, Jesús Marzo
Unknown Affiliation
Audera, Chesús Beltrán
Unknown Affiliation
Medrano, Marta
Unknown Affiliation
Pecondón, Ángela
Unknown Affiliation
Erausquin, Celia
Unknown Affiliation
Ojeda, Soledad
Unknown Affiliation
Quevedo-Abeledo, Juan Carlos
Unknown Affiliation
Francisco, Félix M.
Unknown Affiliation
Lozano, Carlos Rodríguez
Unknown Affiliation
López-Longo, Francisco Javier
Unknown Affiliation
Gerona, Delia
Unknown Affiliation
Fernández, Carlos González
Unknown Affiliation
Monteagudo, Indalecio
Unknown Affiliation
Corrales, Alfonso F.
Unknown Affiliation
Peiró, María Enriqueta
Unknown Affiliation
Senabre, José Miguel
Unknown Affiliation
Rosas, José Carlos
Unknown Affiliation
Rotés, Isabel
Unknown Affiliation
Moreno, Estefanía L.
Unknown Affiliation
Erra, Alba
Unknown Affiliation
Grado, Dolors
Unknown Affiliation
Calvo-Catalá, Javier M.
Unknown Affiliation
Rueda, Amalia
Unknown Affiliation
Möller, Ingrid
Unknown Affiliation
Barbadillo, Carmen
Unknown Affiliation
Raya Álvarez, Enriqué G.
Unknown Affiliation
Magro-Checa, César
Unknown Affiliation
Escribano, Ana Ruibal
Unknown Affiliation
Palmou, Natalia
Unknown Affiliation
Pardo, Silvia Martínez
Unknown Affiliation
Muñoz-Jiménez, Alejandro
Unknown Affiliation
Montero, Sergio Rodríguez
Unknown Affiliation
Redondo, Javier Rivera
Unknown Affiliation
Fernández Carballido, C.
Unknown Affiliation
Naredo, E.
Unknown Affiliation
González, Javier García
Unknown Affiliation
Collantes, Eduardo
Unknown Affiliation
Font, Pilar
Unknown Affiliation
Bonilla-Hernán, Gema
Unknown Affiliation
Aranburu Albizuri, José Miguel
Unknown Affiliation
García-Vivar, María Luz
Unknown Affiliation
Maíz Alonso, Olga
Unknown Affiliation
Calvo-Alén, Jaime
Unknown Affiliation
Miranda-Filloy, José Alberto
Unknown Affiliation
Statistics
Citations: 30
Authors: 105
Affiliations: 19
Identifiers
Doi:
10.1016/j.jacl.2017.02.018
ISSN:
19332874
Research Areas
Cancer
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cohort Study