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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Protection against human papillomavirus type 16-induced tumors in mice using non-genetically modified lactic acid bacteria displaying E7 antigen at its surface
Applied Microbiology and Biotechnology, Volume 97, No. 3, Year 2013
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Description
Human papillomavirus (HPV) is the causative agent of cervical cancer (CxCa) and the most commonly sexually transmitted pathogen worldwide. HPV type 16 (HPV-16) E7 oncoprotein is constitutively produced in CxCa and considered as a good antigen candidate for the development of new therapeutic CxCa vaccines. Here, we report the use of non-genetically modified, E7-expressing lactic acid bacteria (LAB) by using the cell-binding domain from Lactobacillus casei A2 phage lysin as a cell wall anchor. The versatility of this system was validated by investigating E7 stability at the surface of Lactococcus lactis and L. casei, two major species of LAB. Moreover, we demonstrated the successful use of these LAB displaying E7 antigen as a mucosal live vaccine in mice. Altogether, these results show the feasibility of using non-genetically modified LAB for low-cost mucosal immunotherapy against HPV-related CxCa in humans. © 2012 Springer-Verlag Berlin Heidelberg.
Authors & Co-Authors
Ribelles, Pedro
France, Jouy-en-josas
Microbiologie de L'alimentation au Service de la Santé Humaine
Spain, Oviedo
Universidad de Oviedo
Benbouziane, Bouasria
France, Jouy-en-josas
Microbiologie de L'alimentation au Service de la Santé Humaine
Algeria, Mostaganem
Université Abdelhamid Ibn Badis Mostaganem
Langella, Philippe
France, Jouy-en-josas
Microbiologie de L'alimentation au Service de la Santé Humaine
Suárez, Juan E.
Spain, Villaviciosa
Csic - Instituto de Productos Lacteos de Asturias Ipla
Spain, Oviedo
Universidad de Oviedo
Bermúdez-Humarán, Luis Gilberto
France, Jouy-en-josas
Microbiologie de L'alimentation au Service de la Santé Humaine
Riazi, Ali
Algeria, Mostaganem
Université Abdelhamid Ibn Badis Mostaganem
Statistics
Citations: 6
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1007/s00253-012-4575-1
ISSN:
01757598
e-ISSN:
14320614
Research Areas
Cancer