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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Phylogenetic and histological variation in avipoxviruses isolated in South Africa
Journal of General Virology, Volume 94, No. PART10, Year 2013
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Description
Thirteen novel avipoxviruses were isolated from birds from different regions of South Africa. These viruses could be divided into six groups, according to gross pathology and pock appearance on chick chorioallantoic membranes (CAMs). Histopathology revealed distinct differences in epidermal and mesodermal cell proliferation, as well as immune cell infiltration, caused by the different avipoxviruses, even within groups of viruses causing similar CAM gross pathology. In order to determine the genetic relationships among the viruses, several conserved poxvirus genetic regions, corresponding to vaccinia virus (VACV) A3L (fpv167 locus, VACV P4b), G8R (fpv126 locus, VLTF-1), H3L (fpv140 locus, VACV H3L) and A11R-A12L (fpv175-176 locus) were analysed phylogenetically. The South African avipoxvirus isolates in this study all grouped in clade A, in either subclade A2 or A3 of the genus Avipoxvirus and differ from the commercial fowlpox vaccines (subclade A1) in use in the South African poultry industry. Analysis of different loci resulted in different branching patterns. There was no correlation between gross morphology, histopathology, pock morphology and phylogenetic grouping. There was also no correlation between geographical distribution and virus phenotype or genotype. © 2013 SGM.
Authors & Co-Authors
Offerman, Kristy
South Africa, Cape Town
University of Cape Town
Carulei, Olivia
South Africa, Cape Town
University of Cape Town
Gous, Tertius A.
Unknown Affiliation
Douglass, Nicola J.
South Africa, Cape Town
University of Cape Town
Williamson, Anna Lise
South Africa, Cape Town
University of Cape Town
South Africa, Observatory
Groote Schuur Hospital
Statistics
Citations: 45
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1099/vir.0.054049-0
ISSN:
00221317
e-ISSN:
14652099
Research Areas
Genetics And Genomics
Study Locations
South Africa