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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
A novel therapeutic drug (copper nicotinic acid complex) for non-alcoholic fatty liver
Liver International, Volume 27, No. 4, Year 2007
Notification
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Description
Background: Fatty liver is the accumulation of fat in liver cells, which leads to disruption of the normal liver structure and function. Methods: A non-alcoholic fatty liver rat model received copper (Cu) (I)-nicotinate complex [CuCl(HNA)2] for 4 weeks. Results: Clinical signs and histopathological examinations showed obvious improvements in rats that received Cu complex who were continuously on an (HCFF) diet than those returned to standard diet with Cu complex. The improvement was matched in total lipids in sera and hepatic tissue, with disappearance of fat droplets from liver sections. Furthermore, the gain in body weight and the corresponding decrease in liver weight, decreased liver transaminases and alkaline phosphatase were prominent. The oxidative stress markers such as nitric oxide, lipid peroxides, glutathione and superoxide dismutase were obviously changed to healthy normal levels. Conclusion: The Cu complex may serve as a novel chemical restoring agent in fatty degenerated liver cells and for renewal of their structure and functions. However, clinical trials are required for more evaluation of the Cu complex in humans. © 2007 Blackwell Munksgaard.
Authors & Co-Authors
Salama, Ragaa H.M.
Egypt, Asyut
Faculty of Medicine
Nassar, Ahmed Yassein A.
Egypt, Asyut
Faculty of Medicine
Nafady, Alaa Mohamed
Egypt, Asyut
Faculty of Veterinary Medicine
Mohamed, Hesham H.T.
Egypt, Cairo
Faculty of Pharmacy
Statistics
Citations: 35
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1111/j.1478-3231.2007.01460.x
ISSN:
14783223
e-ISSN:
14783231