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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
How important is the 'quality' of the cytotoxic T lymphocyte (CTL) response in protection against HIV infection?
Immunology Letters, Volume 79, No. 1-2, Year 2001
Notification
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Description
Cytotoxic T lymphocyte (CTL) responses have been associated with protection from HIV-1 infection in people with a high degree of exposure to HIV and who show no serological evidence of HIV infection (HEPS, highly exposed persistently seronegative). However, it remains unclear how protective CTL responses could apparently develop in a minority of people, whilst the great majority of HIV-infected people make strong CTL responses yet progress to AIDS and death. In this paper we review the data which supports the hypothesis that the quality of the T-cell response, rather than its magnitude, may be an important factor that merits further investigation. © 2001 Elsevier Science B.V. All rights reserved.
Authors & Co-Authors
Rowland-Jones, Sarah Louise
United Kingdom, Oxford
John Radcliffe Hospital
Pinheiro, Susana
United Kingdom, Oxford
John Radcliffe Hospital
Kaul, Rupert
United Kingdom, Oxford
John Radcliffe Hospital
Hansasuta, Pokrath
United Kingdom, Oxford
John Radcliffe Hospital
Gillespie, Geraldine M.A.
United Kingdom, Oxford
John Radcliffe Hospital
Dong, Tao
United Kingdom, Oxford
John Radcliffe Hospital
Plummer, Francis Allan
Kenya, Nairobi
University of Nairobi
Bwayo, Job J.
Kenya, Nairobi
University of Nairobi
Fidler, Sarah J.
United Kingdom, London
St Mary's Hospital
Weber, Jonathan N.
United Kingdom, London
St Mary's Hospital
McMichael, Andrew James
United Kingdom, Oxford
John Radcliffe Hospital
Appay, Victor A.
United Kingdom, Oxford
John Radcliffe Hospital
Statistics
Citations: 81
Authors: 12
Affiliations: 3
Identifiers
Doi:
10.1016/S0165-2478(01)00261-9
ISSN:
01652478
Research Areas
Infectious Diseases