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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Bacterial vaginosis in HIV-infected women induces reversible alterations in the cervical immune environment
Journal of Acquired Immune Deficiency Syndromes, Volume 49, No. 5, Year 2008
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Description
Background: Bacterial vaginosis (BV) has been associated with increased HIV cervicovaginal shedding. We hypothesized that this might relate to BV-associated increases in mucosal activated CD4+ T cells, which could enhance local HIV replication. Methods: Vaginal flora, cytokine/chemokine levels, and mucosal immune cell populations collected by cervical cytobrush were analyzed in 15 HIV-infected Kenyan female sex workers, before and after BV therapy with oral metronidazole. Results: Therapy reduced the Nugent score in all but 1 participant, and BV elimination was associated with reduced genital levels of interleukin 1β(IL1β), interleukin 8 (IL-8), and Regulated Upon Activation Normal T-cell Expressed and Secreted (RANTES). In addition, BV elimination reduced the total number of cervical CD4+ T cells, including those expressing the HIV coreceptor CCR5 and the activation marker CD69. Conclusions: BV induces significant and reversible alterations in cervical immune cell populations and local inflammatory cytokines that would be expected to enhance local HIV replication. Copyright © 2008 Lippincott Williams & Wilkins.
Authors & Co-Authors
Rebbapragada, Anuradha
Canada, Toronto
University of Toronto
Howe, Kathryn L.
Canada, Toronto
University of Toronto
Wachihi, Charles
Kenya, Nairobi
University of Nairobi
Pettengell, Christopher
Canada, Toronto
University of Toronto
Sunderji, Sherzana
Canada, Toronto
University of Toronto
Huibner, Sanja
Canada, Toronto
University of Toronto
Ball, Terry Blake
Canada, Winnipeg
University of Manitoba
Plummer, Francis Allan
Canada, Winnipeg
University of Manitoba
Jaoko, Walter G.
Kenya, Nairobi
University of Nairobi
Kaul, Rupert
Canada, Toronto
University of Toronto
Kenya, Nairobi
University of Nairobi
Canada, Toronto
University Health Network University of Toronto
Statistics
Citations: 55
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.1097/QAI.0b013e318189a7ca
ISSN:
15254135
Research Areas
Health System And Policy
Infectious Diseases
Sexual And Reproductive Health
Participants Gender
Female