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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Eligibility for isoniazid preventive therapy in South African gold mines
PLoS ONE, Volume 8, No. 11, Article e81376, Year 2013
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Description
Setting: The "Thibela TB" cluster randomised trial of community-wide isoniazid preventive therapy (IPT) to reduce tuberculosis incidence in the South African gold mines. Objectives: To determine the proportion of participants eligible for IPT and the reasons and risk factors for ineligibility, to inform the scale-up of IPT. Design: Cross-sectional survey of participants in intervention clusters (mine shafts) consenting to tuberculosis screening and assessment for eligibility to start IPT. Results: Among 27,126 consenting participants, 94.7% were male, the median age was 41 years, 12.2% reported previous tuberculosis, 0.6% reported ever taking IPT and 2.5% reported currently taking antiretroviral therapy. There were 24,430 (90.1%) assessed as eligible to start IPT, of whom 23,659 started IPT. The most common reasons for ineligibility were having suspected tuberculosis that was subsequently confirmed by a positive smear and/or culture (n=705), excessive alcohol consumption (n=427) and being on tuberculosis treatment at time of initial screen (n=241). Ineligibility was associated with factors including older age, female gender, prior history of tuberculosis and being in "HIV care". However, at least 78% were eligible for IPT in all of these sub-groups. Conclusions: The vast majority of participants in this community-wide intervention were eligible for IPT. © 2013 Lewis et al.
Authors & Co-Authors
Lewis, James J.C.
Unknown Affiliation
Fielding, Katherine Linda
Unknown Affiliation
Grant, Alison D.
Unknown Affiliation
Chihota, Violet N.
Unknown Affiliation
Popane, Flora
Unknown Affiliation
Luttig, Mariëtha M.
Unknown Affiliation
Muller, Dorothy
Unknown Affiliation
Coetzee, Leonie
Unknown Affiliation
Churchyard, Gavin John
Unknown Affiliation
Statistics
Citations: 9
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1371/journal.pone.0081376
e-ISSN:
19326203
Research Areas
Infectious Diseases
Substance Abuse
Study Design
Randomised Control Trial
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Participants Gender
Male
Female