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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Association between conventional risk factors and different ultrasound-based markers of atherosclerosis at carotid and femoral levels in a middle-aged population
International Journal of Cardiovascular Imaging, Volume 29, No. 3, Year 2013
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Description
Ultrasound detection of sub-clinical atherosclerosis (ATS) may help identify individuals at high cardiovascular risk. Most studies evaluated intima-media thickness (IMT) at carotid level. We compared the relationships between main cardiovascular risk factors (CVRF) and five indicators of ATS (IMT, mean and maximal plaque thickness, mean and maximal plaque area) at both carotid and femoral levels. Ultrasound was performed on 496 participants aged 45-64 years randomly selected from the general population of the Republic of Seychelles. 73.4 % participants had ≥1 plaque (IMT thickening ≥1.2 mm) at carotid level and 67.5 % at femoral level. Variance (adjusted R2) contributed by age, sex and CVRF (smoking, LDL-cholesterol, HDL-cholesterol, blood pressure, diabetes) in predicting any of the ATS markers was larger at femoral than carotid level. At both carotid and femoral levels, the association between CVRF and ATS was stronger based on plaque-based markers than IMT. Our findings show that the associations between CVRF and ATS markers were stronger at femoral than carotid level, and with plaque-based markers rather than IMT. Pending comparison of these markers using harder cardiovascular endpoints, our findings suggest that markers based on plaque morphology assessed at femoral artery level might be useful cardiovascular risk predictors. © 2012 Springer Science+Business Media, B.V.
Authors & Co-Authors
Yerly, Patrick
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Seychelles, Mahe
Ministry of Health Seychelles
Rodondi, Nicolas
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Viswanathan, Bharathi
Seychelles, Mahe
Ministry of Health Seychelles
Riesen, Walter F.
Switzerland, Chur
Canton Hospital
Vogt, Pierre
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Bovet, Pascal
Seychelles, Mahe
Ministry of Health Seychelles
Switzerland, Lausanne
Institut Universitaire de Médecine Sociale et Préventive Lausanne
Statistics
Citations: 33
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1007/s10554-012-0124-3
ISSN:
15695794
e-ISSN:
15730743
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Locations
Seychelles